McIver D J, Fields N D, Philp R B
Department of Pharmacology and Toxicology, University of Western Ontario, London, Canada.
Br J Anaesth. 1990 Jan;64(1):77-84. doi: 10.1093/bja/64.1.77.
We have compared the effects of the anaesthetic gases nitrogen and argon on adenosine diphosphate (ADP)-induced human blood platelet aggregation with the effects of the non-anaesthetic gas helium. All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there was a linear relationship between gas pressure and inhibition of aggregation over the range 15-68 atmospheres absolute (atm abs), whereas helium had a threshold for inhibition of approximately 34 atm abs. The inhibition by all gases was reversible after slow decompression. At pressures greater than 55 atm abs, nitrogen produced less inhibition than helium, indicating anaesthetic-pressure antagonism. Whereas pressure alone and the anaesthetic gases inhibited aggregation, the platelet shape change elicited by ADP was resistant to both nitrogen and helium, indicating that ADP binding and the early events in platelet activation were relatively unaffected by these conditions.
我们已将麻醉气体氮气和氩气对二磷酸腺苷（ADP）诱导的人体血小板聚集的影响，与非麻醉气体氦气的影响进行了比较。所有这三种气体均呈现出剂量依赖性的血小板聚集抑制作用。对于氮气和氩气，在绝对压力15至68个大气压（atm abs）范围内，气体压力与聚集抑制之间存在线性关系，而氦气的抑制阈值约为34 atm abs。缓慢减压后，所有气体的抑制作用均可逆转。在压力大于55 atm abs时，氮气产生的抑制作用小于氦气，表明存在麻醉压力拮抗作用。虽然仅压力和麻醉气体就能抑制聚集，但ADP引发的血小板形状变化对氮气和氦气均具有抗性，这表明ADP结合以及血小板激活的早期事件相对不受这些条件的影响。
