Pd(II)催化末端芳基炔与烯丙基醚的脱氢烯烃化反应：线性 (Z)-1,3-烯炔的通用和选择性合成。

Pd(II)-catalyzed dehydrogenative olefination of terminal arylalkynes with allylic ethers: general and selective access to linear (Z)-1,3-enynes.

机构信息

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

出版信息

Org Lett. 2012 Oct 19;14(20):5242-5. doi: 10.1021/ol302400p. Epub 2012 Oct 1.

Abstract

This work demonstrates a green and efficient method to prepare 1,3-enynes via Pd(II)-catalyzed direct dehydrogenative olefination of terminal arylalkynes with unactived allylic ethers. Various terminal arylalkynes can participate in the reaction, stereoselectively affording the desired conjugated (Z)-1,3-enynes in moderate to good yields.

摘要

这项工作展示了一种绿色高效的方法，通过钯（II）催化末端芳炔与非活化烯丙基醚的直接脱氢烯烃化反应来制备 1,3-烯炔。各种末端芳炔可以参与反应，以中等至良好的收率立体选择性地得到所需的共轭（Z）-1,3-烯炔。