Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
J Clin Neurophysiol. 2012 Oct;29(5):468-71. doi: 10.1097/WNP.0b013e31826be029.
This study was undertaken to document the muscle involvement in dengue virus infection using quantitative electromyography (QEMG).
The patients with dengue myopathy were subjected to clinical examination including muscle power, tone, reflex, and sensations. Blood counts, hemoglobin, hematocrit, serum creatine kinase (CK), and electrolytes were determined. The QEMG was performed in the biceps using multimotor unit potential analysis program. Muscle biopsy was done in two patients. At 1 month, their clinical and QEMG analyses were repeated.
Thirteen patients whose median age was 34 years were included. Seven patients had severe and six had mild weakness, which was more marked in proximal lower limb muscles. The median CK level was 480 (300-2,477) U/L. Needle EMG did not reveal any spontaneous activity. The motor unit potentials (MUPs) were of normal to short duration, polyphasic with normal interference pattern. The QEMG revealed a significant change in the duration of MUP at 1 month compared with that of baseline. All the patients clinically and biochemically improved after 1 month. Muscle biopsy revealed interstitial hemorrhage with occasional myonecrosis and myophagocytosis without inflammation or vasculitis.
The QEMG in dengue myopathy revealed improvement in the duration of MUP at 1-month follow-up, which paralleled with clinical and CK improvement.
本研究旨在通过定量肌电图（QEMG）记录登革热病毒感染中的肌肉受累情况。
登革热肌病患者接受了临床检查，包括肌肉力量、张力、反射和感觉。进行了血常规、血红蛋白、血细胞比容、血清肌酸激酶（CK）和电解质检查。使用多运动单位电位分析程序对肱二头肌进行 QEMG 检查。两名患者进行了肌肉活检。在 1 个月时，重复了他们的临床和 QEMG 分析。
纳入了 13 名中位年龄为 34 岁的患者。7 名患者有严重肌无力，6 名患者有轻度肌无力，以下肢近端肌肉更为明显。中位 CK 水平为 480（300-2477）U/L。针极肌电图未发现任何自发性活动。运动单位电位（MUPs）呈正常至短时限，多相，正常干扰模式。与基线相比，1 个月时 QEMG 显示 MUP 持续时间有显著变化。所有患者在 1 个月后临床和生化均有改善。肌肉活检显示间质出血，偶尔有肌坏死和肌吞噬现象，但无炎症或血管炎。
登革热肌病的 QEMG 显示，1 个月随访时 MUP 持续时间改善，与临床和 CK 改善相平行。
