棘白菌素类药物卡泊芬净与两性霉素 B 或伏立康唑体外抗曲霉生物膜的相互作用。
Interaction of the echinocandin caspofungin with amphotericin B or voriconazole against Aspergillus biofilms in vitro.
机构信息
Department of Dermatology and Venereology, Peking University, Beijing, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2012 Dec;56(12):6414-6. doi: 10.1128/AAC.00687-12. Epub 2012 Oct 1.
Abstract
Aspergillus biofilms were prepared from 22 strains of Aspergillus spp. via a 96-well plate-based method. Using a broth microdilution checkerboard technique with the XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] colorimetric assay, we demonstrated a synergistic antifungal activity against 18 of 22 Aspergillus biofilm strains with a combination of caspofungin and amphotericin B and against 13 of 22 strains with a combination of caspofungin and voriconazole. We did not observe antagonism.
摘要
采用 96 孔板法从 22 株曲霉菌株中制备曲霉生物膜。采用 XTT（2,3-双（2-甲氧基-4-硝基-5-磺苯基）-2H-四唑-5-羧酰胺）比色法微量肉汤稀释棋盘试验，我们证明了卡泊芬净和两性霉素 B 联合治疗对 22 株曲霉生物膜菌株中的 18 株具有协同抗真菌活性，而卡泊芬净和伏立康唑联合治疗对 22 株菌株中的 13 株具有协同抗真菌活性。我们没有观察到拮抗作用。
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