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超宽带轴棱锥换能器用于光声内窥镜。

Ultra-broadband axicon transducer for optoacoustic endoscopy.

机构信息

Chair of Biological Imaging, Central Institute for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.

出版信息

Sci Rep. 2021 Jan 18;11(1):1654. doi: 10.1038/s41598-021-81117-7.

Abstract

Image performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus. Current optoacoustic focused transducers achieve lateral resolutions in the range of tens of microns in the mesoscopic regime, but their depth of focus is limited to hundreds of microns by the nature of their spherical geometry. We designed an ultra-broadband axicon detector with a 2 mm central aperture and investigated whether the imaging characteristics exceeded those of a spherical detector of similar size. We show a previously undocumented ability to achieve a broadband elongated pencil-beam optoacoustic sensitivity with an axicon detection geometry, providing approximately 40 μm-lateral resolution maintained over a depth of focus of 950 μm-3.8 times that of the reference spherical detector. This performance could potentially lead to optoacoustic endoscopes that can visualize optical absorption deeper and with higher resolution than any other optical endoscope today.

摘要

成像性能在光声内窥镜显著取决于换能器的设计。理想情况下,需要在扩展的景深上具有高分辨率性能。当前的光声聚焦换能器在介观范围内实现了数十微米的横向分辨率,但由于其球形几何形状的性质,其景深被限制在数百微米。我们设计了一个具有 2mm 中心孔径的超宽带轴棱锥探测器,并研究了其成像特性是否超过了类似尺寸的球形探测器。我们展示了一种以前未记录的能力,即用轴棱锥检测几何形状实现宽带拉长铅笔束光声灵敏度,提供约 40μm 的横向分辨率,在 950μm-3.8 倍的景深范围内保持,比参考球形探测器高 40μm 的横向分辨率。这种性能可能导致光声内窥镜能够比当今任何其他光学内窥镜更深地可视化光学吸收并具有更高的分辨率。

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