Weibel H, Sydler T, Brugnera E, Voets H, Grosse Liesner B, Sidler X
Department for Farm Animals, University of Zurich, Switzerland.
Schweiz Arch Tierheilkd. 2012 Oct;154(10):445-50. doi: 10.1024/0036-7281/a000381.
This study explores administration of two piglet vaccines as compared to the mono- and adjuvant-application. A vaccine against the Porcine Circovirus Type 2 (PCV2) cap protein subunit and a vaccine with attenuated live culture against Lawsonia (L.) intracellularis were applied to piglets aged 23.5 days on average. 1'405 animals were divided randomly into four groups. One piglet group was immunized with both vaccines while two other groups were immunized with a combination of one vaccine and adjuvants of alternate vaccination protocol and vice versa. These piglet groups were also compared to a control group supplemented with both adjuvants only. During fattening, pigs, which were simultaneously immunized with Enterisol(®) Ileitis and Ingelvac(®) CircoFLEX(TM) vaccine, gained significantly more weight (792 g/day) when compared to piglet groups mono-vaccinated with Ingelvac® CircoFLEXTM (772 g/day) or either with Enterisol® Ileitis (774 g/day). Moreover, immunized piglet groups showed significantly higher daily weight gain when compared to adjuvants only inoculated control group (751 g/day). Additionally, during fattening the control group displayed higher mortality (6,3 %) than the three vaccinated groups (Ingelvac(®) CircoFLEX(TM) 2,5 %, Enterisol(®) Ileitis 2,3 % and the combination of both vaccines 1,1 %). These data imply that simultaneous immunization with PCV2- and L. intracellularis specific vaccines positively benefit piglet growth observed by an additive effect on growth parameters in farms harboring both pathogens. Return of investment was calculated of 2.10 on the additional Enterisol(®) Ileitis vaccination.
本研究探讨了两种仔猪疫苗联合接种与单疫苗接种及佐剂接种相比的效果。将针对猪圆环病毒2型（PCV2）衣壳蛋白亚基的疫苗和针对胞内劳森菌（L. intracellularis）的减毒活疫苗应用于平均年龄为23.5天的仔猪。1405只动物被随机分为四组。一组仔猪接种两种疫苗，另外两组分别接种一种疫苗与交替接种方案的佐剂组合，反之亦然。这些仔猪组还与仅添加两种佐剂的对照组进行了比较。在育肥期间，同时接种肠立克（Enterisol®）回肠炎疫苗和英特威（Ingelvac®）圆环疫苗（CircoFLEX™）的猪，与单接种英特威（Ingelvac®）圆环疫苗（CircoFLEX™）（772克/天）或肠立克（Enterisol®）回肠炎疫苗（774克/天）的仔猪组相比，体重显著增加更多（792克/天）。此外，与仅接种佐剂的对照组（751克/天）相比，接种疫苗的仔猪组日增重显著更高。此外，在育肥期间，对照组的死亡率（6.3%）高于三个接种疫苗组（英特威（Ingelvac®）圆环疫苗（CircoFLEX™）为2.5%，肠立克（Enterisol®）回肠炎疫苗为2.3%，两种疫苗联合接种为1.1%）。这些数据表明，在同时存在这两种病原体的农场中，同时接种PCV2和胞内劳森菌特异性疫苗对仔猪生长具有积极益处，通过对生长参数的累加效应得以体现。对额外接种肠立克（Enterisol®）回肠炎疫苗的投资回报率计算为2.10。
