Won Gayeon, Chi Na-Kyoung, Park Yebin
College of Veterinary Medicine, Jeonbuk National University, Iksan Campus, Gobong-ro 79, Iksan 54596, Korea.
Vet Sci. 2022 Sep 28;9(10):536. doi: 10.3390/vetsci9100536.
In this study, a systematic review and meta-analysis was conducted to assess the efficacy of commercial vaccines against PPE in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Of the 373 articles reviewed, 16 fulfilled the pre-specified inclusion criteria. Three independent reviewers extracted the data, and vaccine effectiveness was assessed using the outcomes of interest. The majority of studies had a low or unclear risk of bias as assessed using the ARRIVE guidelines. The results of the meta-analysis indicated that the vaccination resulted in statistically significant reductions in bacterial fecal shedding (odds ratio, OR = 0.122, 95% confidence interval, CI 0.054−0.278) and mortality rate (risk ratio, RR = 0.199; 95% CI, 0.066−0.605). Furthermore, ADWG was significantly increased in the vaccinated pigs compared to the unvaccinated controls (standardized mean difference (SMD) = 0.606, 95% CI 0.243−0.969). In the subgroup analysis, the production phase and study type significantly influenced the effect size (p < 0.1). The Egger’s regression test showed no evidence of publication bias (p > 0.1). The effectiveness of commercially available vaccines against PPE-related weight loss, fecal shedding, and mortality suggests that the vaccines may help control PPE on affected swine farms.
在本研究中，根据系统评价和Meta分析的首选报告项目（PRISMA）清单，进行了一项系统评价和Meta分析，以评估商业疫苗对猪增生性肠炎（PPE）的疗效。在检索的373篇文章中，有16篇符合预先设定的纳入标准。由三名独立评审员提取数据，并使用感兴趣的结果评估疫苗效力。根据ARRIVE指南评估，大多数研究的偏倚风险较低或不明确。Meta分析结果表明，接种疫苗使粪便细菌排出量（优势比，OR = 0.122，95%置信区间，CI 0.054−0.278）和死亡率（风险比，RR = 0.199；95% CI，0.066−0.605）在统计学上显著降低。此外，与未接种疫苗的对照组相比，接种疫苗的猪平均日增重显著增加（标准化均数差（SMD）= 0.606，95% CI 0.243−0.969）。在亚组分析中，生产阶段和研究类型对效应量有显著影响（p < 0.1）。Egger回归检验未显示发表偏倚的证据（p > 0.1）。市售疫苗对与PPE相关的体重减轻、粪便排出和死亡率的有效性表明，这些疫苗可能有助于控制受影响猪场的PPE。
