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内分泌学中的机制。情绪应激在格雷夫斯病病理生理学中的作用。

Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves' disease.

机构信息

Hôpitaux Universitaires Paris-Seine Saint-Denis, Bobigny Cedex, France.

出版信息

Eur J Endocrinol. 2012 Dec 10;168(1):R13-8. doi: 10.1530/EJE-12-0539. Print 2013 Jan.

DOI:10.1530/EJE-12-0539
PMID:23027804
Abstract

The role of stress in the pathophysiology of Graves' disease is suggested by several clinical observations, by recent advances in immunology and by better understanding of autoimmune diseases which provides new insights into potential effects of stress hormones on T helper cell imbalance involved in the pathogenesis of autoimmune diseases. Stress management should therefore be an important part of the treatment of Graves' disease, as stress reduction may improve the effect of therapy. However, this field still requires interventional data to support stress management in the treatment of Graves' disease.

摘要

压力在格雷夫斯病病理生理学中的作用,可由一些临床观察、免疫学的最新进展,以及对自身免疫性疾病的更好理解来证实,这些为压力激素对自身免疫性疾病发病机制中涉及的辅助性 T 细胞失衡的潜在影响提供了新的见解。因此,压力管理应该是格雷夫斯病治疗的一个重要组成部分,因为减轻压力可能会提高治疗效果。然而,该领域仍需要干预数据来支持在格雷夫斯病治疗中进行压力管理。

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1
Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves' disease.内分泌学中的机制。情绪应激在格雷夫斯病病理生理学中的作用。
Eur J Endocrinol. 2012 Dec 10;168(1):R13-8. doi: 10.1530/EJE-12-0539. Print 2013 Jan.
2
[Anomalies of cellular immunity in Graves' disease treated by synthetic antithyroid drugs: effects on prognosis].
Pathol Biol (Paris). 1987 Dec;35(10):1333-8.
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Reduction in the suppressor-inducer T cell subset and increase in the helper T cell subset in thyroid tissue from patients with Graves' disease.格雷夫斯病患者甲状腺组织中抑制诱导性T细胞亚群减少,辅助性T细胞亚群增加。
J Clin Endocrinol Metab. 1987 Jul;65(1):17-23. doi: 10.1210/jcem-65-1-17.
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The decrease in non-specific suppressor T lymphocytes in female hyperthyroid Graves' disease is secondary to the hyperthyroidism.女性甲状腺功能亢进型格雷夫斯病中非特异性抑制性T淋巴细胞的减少继发于甲状腺功能亢进。
Clin Invest Med. 1987 Jul;10(4):337-44.
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Activated (Ia+) T-lymphocytes and their subsets in autoimmune thyroid diseases: analysis by dual laser flow microfluorocytometry.自身免疫性甲状腺疾病中活化的(Ia+)T淋巴细胞及其亚群:双激光流式微量荧光细胞术分析
J Clin Endocrinol Metab. 1986 Feb;62(2):403-9. doi: 10.1210/jcem-62-2-403.
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[Immunologic analysis of Graves' ophthalmopathy and ophthalmic Graves' disease].[格雷夫斯眼病与眼型格雷夫斯病的免疫学分析]
Zhonghua Yan Ke Za Zhi. 1990 May;26(3):162-4.
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Induction of circulating activated suppressor-like T cells by methimazole therapy for Graves' disease.甲巯咪唑治疗Graves病诱导循环中活化的抑制样T细胞产生
N Engl J Med. 1987 Jan 1;316(1):15-22. doi: 10.1056/NEJM198701013160104.
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Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis.格雷夫斯病和桥本甲状腺炎患者血清白细胞介素-5浓度升高。
Thyroid. 1998 Mar;8(3):235-9. doi: 10.1089/thy.1998.8.235.
9
Increase of peripheral B lymphocytes in Graves' disease.格雷夫斯病中外周血B淋巴细胞增多。
Clin Exp Immunol. 1980 Oct;42(1):33-40.
10
Pathophysiology of Graves' disease.格雷夫斯病的病理生理学
Hosp Pract (Off Ed). 1987 May 15;22(5):147-57, 162-4.

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