Hidaka Y, Okumura M, Shimaoka Y, Takeoka K, Tada H, Amino N
Department of Laboratory Medicine, Osaka University Medical School, Suita, Japan.
Thyroid. 1998 Mar;8(3):235-9. doi: 10.1089/thy.1998.8.235.
We investigated serum levels of interleukin-5 (IL-5) in order to examine the role of T-helper 2 (Th2)-type immune response in the pathogenesis of autoimmune thyroid diseases. Serum levels of IL-5 were determined by a highly sensitive sandwich enzyme-linked immunosorbent assay in 42 patients with Graves' disease, 32 patients with Hashimoto's thyroiditis, 12 patients with silent thyroiditis, and 21 normal controls. Compared with serum levels in normal subjects (5.8 +/- 4.2 pg/mL), IL-5 was increased in patients with Graves' disease (16.4 +/- 16.7 pg/mL, p < .01), and in patients with Hashimoto's thyroiditis (10.0 +/- 7.6 pg/mL, p < .05), but not in patients with silent thyroiditis. There was no correlation between serum free thyroxine (FT4) and IL-5 levels. These data suggest an important role of the Th2-type immune response in the pathogenesis of Graves' disease and Hashimoto's thyroiditis.
我们检测了白细胞介素-5（IL-5）的血清水平，以研究辅助性T细胞2（Th2）型免疫反应在自身免疫性甲状腺疾病发病机制中的作用。采用高灵敏度夹心酶联免疫吸附测定法，检测了42例格雷夫斯病患者、32例桥本甲状腺炎患者、12例寂静性甲状腺炎患者及21名正常对照者的血清IL-5水平。与正常受试者血清水平（5.8±4.2 pg/mL）相比，格雷夫斯病患者（16.4±16.7 pg/mL，p<.01）及桥本甲状腺炎患者（10.0±7.6 pg/mL，p<.05）的IL-5水平升高，而寂静性甲状腺炎患者的IL-5水平未升高。血清游离甲状腺素（FT4）与IL-5水平之间无相关性。这些数据表明，Th2型免疫反应在格雷夫斯病和桥本甲状腺炎的发病机制中起重要作用。
