Redondo Santiago, Navarro-Dorado Jorge, Ramajo Marta, Medina Úrsula, Tejerina Teresa
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Vasc Health Risk Manag. 2012;8:533-9. doi: 10.2147/VHRM.S28041. Epub 2012 Sep 13.
Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-β1 pathway to diagnosis and therapeutics.
转化生长因子β（TGF-β1）是一种多效性细胞因子，在细胞和组织生理学中具有多种复杂作用。这得益于一个非常复杂且相互交织的信号系统，其调控仍是越来越多研究的焦点。这种复杂的调控在心血管生理学、止血和血管界面中发挥着关键作用。据此，TGF-β1通路在相关疾病（如动脉粥样硬化性血管疾病和骨髓增殖性综合征）中似乎失调。预计越来越多的实验和临床研究将在把TGF-β1通路知识应用于诊断和治疗方面取得医学进展。
