• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雏菊叶龙胆苷纳米胶束的制备、表征及研究

Preparation, characterization and study of bellidifolin nano-micelles.

作者信息

Gao Fan, Chen Ziyue, Zhou Li, Xiao Xuefeng, Wang Lin, Liu Xingchao, Wang Chenggang, Guo Qiuhong

机构信息

Hebei TCM Formula Preparation Technology Innovation Center, Hebei University of Chinese Medicine Shijiazhuang 050091 People's Republic of China

School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin 301617 People's Republic of China.

出版信息

RSC Adv. 2022 Aug 10;12(34):21982-21989. doi: 10.1039/d2ra02779h. eCollection 2022 Aug 4.

DOI:10.1039/d2ra02779h
PMID:36043071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364364/
Abstract

Bellidifolin (BEL), a xanthone compound, has significant therapeutic effectiveness in cardiac diseases such as arrhythmias. However, BEL is limited in clinical applications by its hydrophobicity. In this work, we used BEL as the active pharmaceutical ingredient (API), and polyethylene glycol 15-hydroxy stearate (Kolliphor HS15) as the carrier to prepare BEL nano-micelles by a solvent-volatilization method. According to an analysis by differential scanning calorimetry (DSC), BEL was successfully encapsulated in HS15 as BEL nano-micelles with a 90% encapsulation rate, and particle size was 12.60 ± 0.074 nm in the shape of a sphere and electric potential was -4.76 ± 4.47 mV with good stability and sustained release characteristics. In addition, compared with free drugs, these nano-micelles can increase cellular uptake capacity, inhibit the proliferation of human cardiac fibroblasts, and down-regulate the expression of Smad-2, α-SMA, Collagen I, and Collagen III proteins in myocardial cells to improve myocardial fibrosis. In conclusion, the BEL nano-micelles can provide a new way for the theoretical basis for the clinical application of anti-cardiac fibrosis.

摘要

雏菊叶龙胆酮（BEL）是一种呫吨酮化合物，在心律失常等心脏疾病中具有显著的治疗效果。然而，BEL因其疏水性而在临床应用中受到限制。在本研究中，我们以BEL作为活性药物成分（API），聚乙二醇15-羟基硬脂酸酯（科利凡HS15）作为载体，通过溶剂挥发法制备了BEL纳米胶束。差示扫描量热法（DSC）分析表明，BEL成功地以90%的包封率被包裹在HS15中形成BEL纳米胶束，其粒径为12.60±0.074nm，呈球形，电位为-4.76±4.47mV，具有良好的稳定性和缓释特性。此外，与游离药物相比，这些纳米胶束可提高细胞摄取能力，抑制人心脏成纤维细胞的增殖，并下调心肌细胞中Smad-2、α-SMA、I型胶原蛋白和III型胶原蛋白的表达，以改善心肌纤维化。总之，BEL纳米胶束可为抗心肌纤维化临床应用的理论基础提供新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/58d11c6fd96f/d2ra02779h-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/847c305bf949/d2ra02779h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/226cb0704c5b/d2ra02779h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/120ed2925499/d2ra02779h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/56977a36d51b/d2ra02779h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/b8e30b232161/d2ra02779h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/fc3c5bbb6a48/d2ra02779h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/b377cf3afc56/d2ra02779h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/fdd006adef63/d2ra02779h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/1415be65f2b7/d2ra02779h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/9f25499188ee/d2ra02779h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/0a324a533ae9/d2ra02779h-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/19907fccd7b1/d2ra02779h-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/58d11c6fd96f/d2ra02779h-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/847c305bf949/d2ra02779h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/226cb0704c5b/d2ra02779h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/120ed2925499/d2ra02779h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/56977a36d51b/d2ra02779h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/b8e30b232161/d2ra02779h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/fc3c5bbb6a48/d2ra02779h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/b377cf3afc56/d2ra02779h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/fdd006adef63/d2ra02779h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/1415be65f2b7/d2ra02779h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/9f25499188ee/d2ra02779h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/0a324a533ae9/d2ra02779h-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/19907fccd7b1/d2ra02779h-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c418/9364364/58d11c6fd96f/d2ra02779h-f13.jpg

相似文献

1
Preparation, characterization and study of bellidifolin nano-micelles.雏菊叶龙胆苷纳米胶束的制备、表征及研究
RSC Adv. 2022 Aug 10;12(34):21982-21989. doi: 10.1039/d2ra02779h. eCollection 2022 Aug 4.
2
Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization.山金车二醇通过调节TGF-β1/Smads和p38信号通路以及阻止NR4A1的细胞质定位来改善异丙肾上腺素诱导的心肌纤维化。
Front Pharmacol. 2021 Apr 30;12:644886. doi: 10.3389/fphar.2021.644886. eCollection 2021.
3
Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF- Signalling Activation to Ameliorate Myocardial Fibrosis.雏菊叶龙胆苷通过抑制SRY相关高迁移率族盒基因9来阻断转化生长因子信号激活，从而改善心肌纤维化。
Evid Based Complement Alternat Med. 2022 May 9;2022:6841276. doi: 10.1155/2022/6841276. eCollection 2022.
4
Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability.Kolliphor® HS 15 胶束用于辅酶 Q10 的递送：制备、表征和稳定性。
AAPS PharmSciTech. 2016 Jun;17(3):757-66. doi: 10.1208/s12249-015-0399-5. Epub 2015 Sep 4.
5
Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity.毛连菜黄素通过调节STAT3/COX-2表达和蛋白活性抑制A549细胞增殖。
J Oncol. 2020 Nov 21;2020:1723791. doi: 10.1155/2020/1723791. eCollection 2020.
6
Sulforaphane delivery using mPEG-PCL co-polymer nanoparticles to breast cancer cells.使用 mPEG-PCL 共聚物纳米粒子向乳腺癌细胞递送磺酰基丙烯酰胺。
Pharm Dev Technol. 2017 Aug;22(5):642-651. doi: 10.3109/10837450.2016.1146296. Epub 2016 Feb 25.
7
Thymoquinone-Loaded Soluplus-Solutol HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration.负载姜黄素的 Soluplus-Solutol HS15 混合胶束的制备、体外特性评价及其对 SH-SY5Y 细胞迁移的影响。
Molecules. 2020 Oct 14;25(20):4707. doi: 10.3390/molecules25204707.
8
Development and evaluation of a novel drug delivery: Soluplus/TPGS mixed micelles loaded with piperine in vitro and in vivo.新型药物递送系统的研制与评价：Soluplus/TPGS 混合胶束载胡椒碱的体内外研究。
Drug Dev Ind Pharm. 2018 Sep;44(9):1409-1416. doi: 10.1080/03639045.2018.1472277. Epub 2018 May 27.
9
Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation.基于聚氧 15 羟基硬脂酸酯的超小胶束用于杨梅素的眼部递药：优化、体外和体内评价。
Drug Deliv. 2019 Dec;26(1):158-167. doi: 10.1080/10717544.2019.1568624.
10
[Preparation of paclitaxel-loaded and folic acid-modified poly (lactic-co-glycolic acid) nano-micelles and in vitro anticancer effect on cervical cancer HeLa cells].紫杉醇负载及叶酸修饰的聚乳酸-羟基乙酸共聚物纳米胶束的制备及其对宫颈癌HeLa细胞的体外抗癌作用
Zhongguo Zhong Yao Za Zhi. 2021 May;46(10):2481-2488. doi: 10.19540/j.cnki.cjcmm.20210302.303.

引用本文的文献

1
Development of folic acid modified reduction-responsive micelles for the targeted release of sorafenib in liver cancer.叶酸修饰的还原响应性胶束用于索拉非尼在肝癌中的靶向释放的研究进展
Ther Deliv. 2025 Jul;16(7):637-649. doi: 10.1080/20415990.2025.2513223. Epub 2025 May 30.
2
Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy.载有姜黄素和淫羊藿苷的可吸入性TPGS/DPPC胶束用于靶向肺癌治疗
ACS Omega. 2025 Apr 11;10(15):15400-15411. doi: 10.1021/acsomega.5c00008. eCollection 2025 Apr 22.
3
Engineering Ferroptosis Inhibitors as Inhalable Nanomedicines for the Highly Efficient Treatment of Idiopathic Pulmonary Fibrosis.

本文引用的文献

1
Lithocholic acid-tryptophan conjugate (UniPR126) based mixed micelle as a nano carrier for specific delivery of niclosamide to prostate cancer via EphA2 receptor.基于胆酸-色氨酸轭合物（UniPR126）的混合胶束作为纳米载体，通过 EphA2 受体特异性递送至前列腺癌的尼氯硝唑。
Int J Pharm. 2021 Aug 10;605:120819. doi: 10.1016/j.ijpharm.2021.120819. Epub 2021 Jun 22.
2
Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization.山金车二醇通过调节TGF-β1/Smads和p38信号通路以及阻止NR4A1的细胞质定位来改善异丙肾上腺素诱导的心肌纤维化。
Front Pharmacol. 2021 Apr 30;12:644886. doi: 10.3389/fphar.2021.644886. eCollection 2021.
3
工程化铁死亡抑制剂作为可吸入纳米药物用于特发性肺纤维化的高效治疗
Bioengineering (Basel). 2023 Jun 17;10(6):727. doi: 10.3390/bioengineering10060727.
In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-β1-induced collagen gel contraction.
在心脏成纤维细胞中，干扰素-β可减弱其分化、胶原合成以及 TGF-β1 诱导的胶原凝胶收缩。
Cytokine. 2021 Feb;138:155359. doi: 10.1016/j.cyto.2020.155359. Epub 2020 Nov 5.
4
Polymeric micelles for anticancer drug delivery.用于抗癌药物递送的聚合物胶束。
Ther Deliv. 2020 Oct;11(10):613-635. doi: 10.4155/tde-2020-0008. Epub 2020 Sep 15.
5
Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles.利用可生物降解的纳米胶束提高姜黄素的抗结肠癌活性。
J Mater Chem B. 2013 Nov 14;1(42):5778-5790. doi: 10.1039/c3tb21091j. Epub 2013 Sep 19.
6
The aqueous extract of Gentianella acuta improves isoproterenol‑induced myocardial fibrosis via inhibition of the TGF‑β1/Smads signaling pathway.龙胆属植物水提物通过抑制 TGF-β1/Smads 信号通路改善异丙肾上腺素诱导的心肌纤维化。
Int J Mol Med. 2020 Jan;45(1):223-233. doi: 10.3892/ijmm.2019.4410. Epub 2019 Nov 21.
7
Effects of the isothiocyanate sulforaphane on TGF-β1-induced rat cardiac fibroblast activation and extracellular matrix interactions.异硫氰酸酯萝卜硫素对 TGF-β1 诱导的大鼠心肌成纤维细胞激活及细胞外基质相互作用的影响。
J Cell Physiol. 2019 Aug;234(8):13931-13941. doi: 10.1002/jcp.28075. Epub 2019 Jan 4.
8
Protective role of Gentianella acuta on isoprenaline induced myocardial fibrosis in rats via inhibition of NF-κB pathway.獐芽菜对异丙肾上腺素诱导的大鼠心肌纤维化的保护作用：通过抑制 NF-κB 通路。
Biomed Pharmacother. 2019 Feb;110:733-741. doi: 10.1016/j.biopha.2018.12.029. Epub 2018 Dec 13.
9
Chemical Composition, Antioxidant and Anticholinesterase Activities of Gentianella azurea from Russian Federation.俄罗斯联邦蓝白龙胆的化学成分、抗氧化及抗胆碱酯酶活性
Nat Prod Commun. 2017 Jan;12(1):55-56.
10
Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors.利用聚合物胶束的多功能方法来规避多药耐药肿瘤。
Colloids Surf B Biointerfaces. 2019 Jan 1;173:581-590. doi: 10.1016/j.colsurfb.2018.10.022. Epub 2018 Oct 10.