Waeber B, Feihl F
Division de physiopathologie clinique, PPA MP 14/204, CHUV, 1011 Lausanne.
Rev Med Suisse. 2012 Sep 12;8(353):1699-701.
Thiazide (hydrochlorothiazide,...) and thiazide-like (chlortalidone, indapamide,...) diuretics are widely used to treat hypertensive patients. There is growing evidence that these diuretics are not interchangeable and that it might be preferable to choose a thiazide-like diuretic whenever the use of a diuretic is considered. This is in order to prevent optimally the development of cardiovascular complications and the occurrence of metabolic side effects, in particular diabetes.
噻嗪类(氢氯噻嗪等)和类噻嗪类(氯噻酮、吲达帕胺等)利尿剂被广泛用于治疗高血压患者。越来越多的证据表明,这些利尿剂并非可相互替代,并且在考虑使用利尿剂时,选择类噻嗪类利尿剂可能更为可取。这是为了最大程度地预防心血管并发症的发生以及代谢副作用的出现,尤其是糖尿病。