Nakken K O, Bjørholt P G, Johannessen S I, Løyning T, Lind E
National Center for Epilepsy, Sandvika, Norway.
Epilepsia. 1990 Jan-Feb;31(1):88-94. doi: 10.1111/j.1528-1157.1990.tb05365.x.
Twenty-one adult in-patients (11 women, 10 men, aged 18-39 years) with uncontrolled epilepsy participated in a 4-week intensive physical training program, exercising for at least 45 min three times a day, 6 days a week, at an intensity of minimum 60% of maximum oxygen uptake (maximum VO2). The program induced a considerable increase in maximum VO2 (mean 19%). Beneficial psychological and social effects were also recorded. The average seizure frequency during the 4-week exercise period was compared with 2 preexercise and 2 postexercise weeks. There was no significant difference, but there was considerable variation among patients. Only six patients had seizures during exercise. The occurrence had no relation to seizure type, mode of activity, or pulse rate. We conclude that physical activity does not represent an important seizure-inducing factor in general, and that in most people with epilepsy physical training appears to have a favorable influence. The exact mechanism behind this influence is not known, but physiologic as well as psychological and social effects may be of importance. Physical training did not change the serum levels of the antiepileptic drugs to a clinically important degree.
21名患有未得到控制的癫痫的成年住院患者（11名女性，10名男性，年龄在18至39岁之间）参加了一项为期4周的强化体育训练项目，每天锻炼至少45分钟，每周6天，强度至少为最大摄氧量（最大VO2）的60%。该项目使最大VO2显著增加（平均增加19%）。还记录到了有益的心理和社会效应。将4周锻炼期内的平均癫痫发作频率与锻炼前2周和锻炼后2周进行了比较。没有显著差异，但患者之间存在相当大的差异。只有6名患者在锻炼期间发作。发作与癫痫发作类型、活动方式或脉搏率无关。我们得出结论，一般而言，体育活动并非重要的诱发癫痫因素，而且在大多数癫痫患者中，体育训练似乎具有有益影响。这种影响背后的确切机制尚不清楚，但生理以及心理和社会效应可能都很重要。体育训练并未使抗癫痫药物的血清水平发生具有临床意义的变化。
