Sharma Ayushe A, Mackensie Terry D, Popp Johanna L, Szaflarski Jerzy P, Martin Roy C, Nenert Rodolphe, Kaur Manmeet, Brokamp Gabrielle A, Bolding Mark, Allendorfer Jane B
University of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA.
University of Alabama at Birmingham (UAB), Department of Neurobiology, Birmingham, AL, USA.
Epilepsy Behav Rep. 2023 Dec 30;25:100643. doi: 10.1016/j.ebr.2023.100643. eCollection 2024.
Regular physical activity may promote beneficial neuroplasticity, e.g., increased hippocampus volume. However, it is unclear whether self-reported physical exercise in leisure (PEL) levels are associated with the brain structure features demonstrated by exercise interventions. This pilot study investigated the relationship between PEL, mood, cognition, and neuromorphometry in patients with idiopathic generalized epilepsy (IGEs) compared to healthy controls (HCs). Seventeen IGEs and 19 age- and sex-matched HCs underwent magnetic resonance imaging (MRI) at 3T. The Baecke Questionnaire of Habitual Physical Activity, Profile of Mood States, and Montreal Cognitive Assessment (MoCA) assessed PEL, mood, and cognition, respectively. Structural MRI data were analyzed by voxel- and surface-based morphometry. IGEs had significantly lower PEL ( < 0.001), poorer mood ( = 0.029), and lower MoCA scores ( = 0.027) than HCs. These group differences were associated with reduced volume, decreased gyrification, and altered surface topology (IGEs < HCs) in frontal, temporal and cerebellar regions involved in executive function, memory retrieval, and emotional regulation, respectively. These preliminary results support the notion that increased PEL may promote neuroplasticity in IGEs, thus emphasizing the role of physical activity in promoting brain health in people with epilepsy.
规律的体育活动可能促进有益的神经可塑性，例如增加海马体体积。然而，休闲时自我报告的体育锻炼（PEL）水平是否与运动干预所显示的脑结构特征相关尚不清楚。这项前瞻性研究调查了特发性全身性癫痫（IGEs）患者与健康对照者（HCs）的PEL、情绪、认知和神经形态测量之间的关系。17名IGEs患者和19名年龄及性别匹配的HCs接受了3T磁共振成像（MRI）检查。分别通过贝克习惯性身体活动问卷、情绪状态剖面图和蒙特利尔认知评估量表（MoCA）评估PEL、情绪和认知。通过基于体素和表面的形态测量法分析结构MRI数据。与HCs相比，IGEs患者的PEL显著更低（<0.001）、情绪更差（=0.029）且MoCA评分更低（=0.027）。这些组间差异分别与涉及执行功能、记忆检索和情绪调节的额叶、颞叶和小脑区域的体积减小、脑回形成减少以及表面拓扑结构改变（IGEs<HCs）相关。这些初步结果支持了增加PEL可能促进IGEs患者神经可塑性的观点，从而强调了体育活动在促进癫痫患者脑健康中的作用。
