Akpınar Evrim Eylem, Akpınar Serdar, Ertek Sibel, Sayın Esen, Gülhan Meral
Department of Chest Diseases, Ufuk University, Ankara, Turkey.
Tuberk Toraks. 2012;60(3):230-7.
Chronic obstructive pulmonary disease (COPD) has extrapulmonary effects that seems to be related with systemic inflammation. The relationship between metabolic syndrome which is an important determinant of systemic inflammation in general population and COPD is still not clear. The aim of the current study was to investigate the frequency of metabolic syndrome and C-reactive protein (CRP) levels, as a marker of systemic inflammation in stable COPD patients with different severity levels and in age and sex matched control group.
Ninety-one stable COPD patients and 42 control subjects were included in the study. The severity level in patients with COPD were determined according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria. ATP III (The National Cholesterol Education Program's Adult Treatment Panel III) was used in diagnosis of metabolic syndrome. Hs-CRP levels were measured in venous samples of patients and control subjects.
The frequency of metabolic syndrome was found higher in patient group than control subjects, especially in GOLD stages I, II (p= 0.004). Abdominal obesity, hypertension, hyperglycemia components of metabolic syndrome were significantly more prevalent in patient group (p< 0.0001). Increased CRP levels were higher in control and patient groups in all GOLD stages, with metabolic syndrome than without metabolic syndrome (p= 0.047, p= 0.217, p< 0.001, p= 0.05, p= 0.467).
The study showed that frequency of metabolic syndrome was higher in stable COPD patients than control subjects and general Turkish population. Abdominal obesity, hypertension and hyperglycemia were significantly more prevalent in patient group. Systemic inflammation was more intense in COPD patients with metabolic syndrome than without metabolic syndrome.
慢性阻塞性肺疾病（COPD）具有肺外效应，似乎与全身炎症有关。代谢综合征作为普通人群全身炎症的一个重要决定因素，与COPD之间的关系仍不明确。本研究的目的是调查不同严重程度的稳定期COPD患者以及年龄和性别匹配的对照组中代谢综合征的发生率和作为全身炎症标志物的C反应蛋白（CRP）水平。
本研究纳入了91例稳定期COPD患者和42例对照受试者。根据全球慢性阻塞性肺疾病倡议（GOLD）标准确定COPD患者的严重程度。采用美国国家胆固醇教育计划成人治疗专家组第三次报告（ATP III）诊断代谢综合征。测量患者和对照受试者静脉血样中的高敏CRP水平。
发现患者组代谢综合征的发生率高于对照组，尤其是在GOLD I、II期（p = 0.004）。代谢综合征的腹型肥胖、高血压、高血糖成分在患者组中明显更为普遍（p < 0.0001）。在所有GOLD分期中，有代谢综合征的对照组和患者组的CRP水平升高幅度均高于无代谢综合征者（p = 0.047、p = 0.217、p < 0.001、p = 0.05、p = 0.467）。
该研究表明，稳定期COPD患者代谢综合征的发生率高于对照组和土耳其普通人群。腹型肥胖、高血压和高血糖在患者组中明显更为普遍。有代谢综合征的COPD患者的全身炎症比无代谢综合征者更强烈。
