Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
APMIS. 2013 Apr;121(4):311-5. doi: 10.1111/apm.12000. Epub 2012 Sep 13.
Mannose-binding lectin (MBL) is an important molecule of the innate immunity. The low level of MBL in the serum is associated with increased susceptibility to respiratory infections. In this study, MBL concentrations were determined from the sera of 125 Finnish pertussis patients and from 430 control subjects. Severe MBL deficiency (<50 ng/mL) was found more often in the patients than in the controls (11.2% vs 5.8%, p = 0.038). Moreover, the deficiency was detected more frequently in the adult patients than in the controls [20.4% vs 8.6%, p = 0.021; odds ratio 2.7 (95% confidence interval 1.1-6.5)]. Our findings suggest, for the first time, that MBL deficiency predisposes to pertussis infection, at least in adults.
甘露聚糖结合凝集素（MBL）是先天免疫的重要分子。血清中 MBL 水平低与呼吸道感染易感性增加有关。在这项研究中，从 125 名芬兰百日咳患者和 430 名对照者的血清中测定了 MBL 浓度。患者中严重的 MBL 缺乏症（<50ng/ml）比对照组更常见（11.2%比 5.8%，p=0.038）。此外，成人患者中缺乏症的检出率高于对照组[20.4%比 8.6%，p=0.021；比值比 2.7（95%置信区间 1.1-6.5）]。我们的研究结果首次表明，MBL 缺乏至少在成人中易患百日咳感染。
