Wang Etienne Ce, Kwah Yung Chien, Tan Wee Ping, Lee Joyce Ss, Tan Suat Hoon
National Skin Centre, Singapore.
Dermatol Online J. 2012 Sep 15;18(9):4.
Extra-mammary Paget disease (EMPD) is a rare intra-epithelial carcinoma that is usually found on the apocrine-rich skin of the perineum. We report 2 cases in which EMPD was initially misdiagnosed on the initial punch biopsy as melanoma-in-situ and Bowen disease respectively. Reasons for the misdiagnoses included a rare pigmented axillary variant of EMPD in the first case and atypical bowenoid features on H&E in the second. The cases are described with a critical review of the histopathological findings, along with a review of the current literature. This highlights the necessity of a comprehensive immunohistochemical panel for the assessment of intra-epithelial pagetoid atypical cells.
乳腺外佩吉特病（EMPD）是一种罕见的上皮内癌，通常发生于会阴富含顶泌汗腺的皮肤。我们报告2例病例，最初在初次切取活检时，EMPD分别被误诊为原位黑素瘤和鲍温病。误诊原因包括：第一例为罕见的色素沉着性腋窝型EMPD，第二例为苏木精-伊红染色（H&E）显示的非典型鲍温样特征。本文描述了这些病例，并对组织病理学发现进行了批判性回顾，同时回顾了当前的文献。这凸显了采用全面免疫组化检测来评估上皮内佩吉特样非典型细胞的必要性。
