Dhar Subhra, Gupta Divya, Chakraborty Aditi, Malakar Rajib, Dhar Sandipan
From the Department of Histopathology, WIZDERMPATHLAB, Kolkata, India.
Department of Dermatology, Dr. B.R. Ambedkar Medical College and Hospital, Bengaluru, Karnataka, India.
Indian J Dermatol. 2023 Jul-Aug;68(4):488. doi: 10.4103/ijd.ijd_99_23.
Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent plaque with crusting and erosion was the most common presentation, hyperpigmentation, hypopigmentation and depigmentation were also observed in two patients. Characteristic Paget's cells with cytokeratin 7 and EMA positivity were seen on histopathology examination. Authors conclude that pigmentary alterations may be under-reported in extra mammary Paget's disease in the skin of colour.
乳腺外佩吉特病是一种上皮内肿瘤，通常见于顶泌汗腺集中的区域。本文描述了5例患者（3例女性，2例男性）的临床特征、组织病理学、免疫组化及治疗细节。虽然界限清楚的持续性斑块伴结痂和糜烂是最常见的表现，但两名患者还出现了色素沉着、色素减退和色素脱失。组织病理学检查可见具有细胞角蛋白7和上皮膜抗原阳性的特征性佩吉特细胞。作者得出结论，在有色人种皮肤的乳腺外佩吉特病中，色素改变可能未得到充分报道。
