Caillier I, Bannwarth B, Monot C, Lapicque F, Netter P, Gaucher A, Royer R J
Laboratoire de Pharmacologie et Clinique Rhumatologique, URA CNRS 1288, Faculté de Médecine, Vandoeuvre-Les-Nancy, France.
Int J Clin Pharmacol Ther Toxicol. 1990 Jan;28(1):7-13.
Protein binding of sodium salicylate in synovial fluid and in serum from 23 inpatients with rheumatic diseases were studied, ex vivo, by equilibrium dialysis. Scatchard model with two classes of sites was used as a mathematical tool. At therapeutic concentrations, protein binding of sodium salicylate was significantly higher in serum than in synovial fluid. The ratio of areas under the curves for bound concentrations for synovial fluid to that for serum was 0.867. This difference was attributed to the hypoalbuminemia observed in the synovial fluid; for a given molar ratio of drug to albumin, or in other words, for the same amount of available drug per mole of albumin. The number of sites occupied was the same in the two biological media.
采用平衡透析法对23例住院风湿病患者的滑液和血清中水杨酸钠的蛋白结合情况进行了体外研究。使用具有两类结合位点的Scatchard模型作为数学工具。在治疗浓度下，血清中水杨酸钠的蛋白结合率显著高于滑液。滑液与血清中结合浓度曲线下面积之比为0.867。这种差异归因于滑液中观察到的低白蛋白血症；对于给定的药物与白蛋白摩尔比，或者换句话说，对于每摩尔白蛋白中相同量的可用药物，两种生物介质中被占据的位点数量相同。
