Artiko V, Sobic-Saranovic D, Pavlovic S, Petrovic M, Zuvela M, Antic A, Matic S, Odalovic S, Petrovic N, Milovanovic A, Obradovic V
Faculty of Medicine, University of Belgrade, Serbia.
J BUON. 2012 Jul-Sep;17(3):537-42.
To assess the value of whole body scintigraphy using (99m)Tc-HYNIC-TOC (Tektrotyd) and with single photon emission computerized tomography (SPECT) in the detection of primary and metastatic neuroendocrine tumors (NETs).
Thirty patients with different neuroendocrine tumors, mainly gastroenteropancreatic (GEP), were investigated. Whole body scintigraphy was performed 2 h (if necessary 10 min and 24h) after i.v. administration of 740 Mbq (99m)Tc-Tektrotyd, Polatom. In cases of unclear findings obtained by whole body scintigraphy, investigation was followed by SPECT.
From 12 patients with NETs of unknown origin, there were 10 true positive (TP), and 2 false negative (FN) findings. Diagnosis was made with SPECT in 6 patients. From 8 patients with gut carcinoids, there were 4 TP, 2 true negative (TN), one FN, and one false positive (FP) finding. Diagnosis was made with SPECT in 2 patients. From 7 patients with neuroendocrine pancreatic carcinomas there were 4 TP and 3 TN findings. Diagnosis was made with SPECT in 2 patients. From 3 patients with gastrinomas there were 2 TP findings and one TN findings. Diagnosis was made with SPECT findings in 2 patients. Sensitivity of (99m)Tc-HYNIC-TOC was 87%, specificity 86%, positive predictive value 95%, negative predictive value 67% and accuracy 87%.
We concluded that scintigraphy with (99m)Tc-Tektrotyd is an useful method for diagnosis, staging and follow up of the patients with NETs.
评估使用（99m）Tc-HYNIC-TOC（Tektrotyd）及单光子发射计算机断层扫描（SPECT）进行全身闪烁扫描在检测原发性和转移性神经内分泌肿瘤（NETs）中的价值。
对30例患有不同神经内分泌肿瘤（主要为胃肠胰神经内分泌肿瘤）的患者进行了研究。静脉注射740兆贝可（99m）Tc-Tektrotyd（Polatom）后2小时（必要时10分钟和24小时）进行全身闪烁扫描。若全身闪烁扫描结果不明确，则进行SPECT检查。
在12例原发灶不明的NETs患者中，有10例假阳性（TP），2例假阴性（FN）结果。6例患者通过SPECT确诊。在8例肠道类癌患者中，有4例TP，2例真阴性（TN），1例FN和1例假阳性（FP）结果。2例患者通过SPECT确诊。在7例神经内分泌胰腺癌患者中，有4例TP和3例TN结果。2例患者通过SPECT确诊。在3例胃泌素瘤患者中，有2例TP结果和1例TN结果。2例患者通过SPECT结果确诊。（99m）Tc-HYNIC-TOC的敏感性为87%，特异性为86%，阳性预测值为95%，阴性预测值为67%，准确性为87%。
我们得出结论，（99m）Tc-Tektrotyd闪烁扫描是诊断、分期和随访NETs患者的一种有用方法。
