Chen Hong, Li Yi, Gao Xia, Shen Xiaohui
Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China; Research Institution of Otolaryngology, NO. 321 Zhongshan Road, Nanjing 210008, Jiangsu, China.
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Clin Imaging. 2018 Nov-Dec;52:365-369. doi: 10.1016/j.clinimag.2018.09.010. Epub 2018 Sep 20.
To evaluate the diagnostic value of Tc-HYNIC-TOC SPECT/CT in the detection of primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses.
From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body Tc-HYNIC-TOC SPECT/CT scan.
All 19 primary lesions were detected by Tc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of Tc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of Tc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods.
Tc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.
评估Tc-HYNIC-TOC SPECT/CT在鼻腔和鼻窦原发性小细胞神经内分泌癌检测中的诊断价值。
2005年9月至2015年11月，19例鼻窦小细胞神经内分泌癌（SNEC）患者（平均年龄53.9岁，范围37 - 77岁；男性6例，女性13例）接受了全身Tc-HYNIC-TOC SPECT/CT扫描。
Tc-HYNIC-TOC SPECT/CT检测出所有19个原发性病灶。通过基于器官的分析共识别出212个转移病灶，Tc-HYNIC-TOC SPECT/CT的敏感性和特异性分别为90.5%和92.3%。与形态学成像方法相比，应用Tc-HYNIC-TOC SPECT/CT使11例患者（57.9%）检测到更多病灶，7例患者（36.8%）成功改变了治疗方案。
Tc-HYNIC-TOC闪烁扫描术是检测鼻窦SNEC的有效方法。
