Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Anaesthesia. 2012 Dec;67(12):1370-4. doi: 10.1111/anae.12020. Epub 2012 Oct 3.
Uncontrolled studies suggest that magnesium sulphate controls spasms in patients with established tetanus. We performed a meta-analysis of controlled trials that compared magnesium sulphate with placebo or diazepam for the treatment of patients with tetanus. We searched PubMed, Scopus, Embase and the Cochrane clinical trials registry. Three studies met the inclusion criteria, containing 275 participants (199 male patients, 72.4%). Magnesium sulphate did not reduce mortality, relative risk (95% CI): vs placebo, 0.80 (0.41-1.58); vs diazepam, 1.11 (0.70-1.75). The data on duration of total intensive care unit stay, total hospital stay and the need for ventilatory support were conflicting and pooling of results could not be done due to methodological differences of individual trials. More controlled trials are needed to assess the effect of magnesium sulphate on reducing autonomic instability, spasms, duration of intensive care and hospital stays and the need for mechanical ventilation.
未控制的研究表明，硫酸镁可控制已确诊破伤风患者的痉挛。我们对比较硫酸镁与安慰剂或地西泮治疗破伤风患者的对照试验进行了荟萃分析。我们检索了 PubMed、Scopus、Embase 和 Cochrane 临床试验注册库。三项研究符合纳入标准，包含 275 名参与者（199 名男性患者，72.4%）。硫酸镁并未降低死亡率，相对风险（95%CI）：与安慰剂相比，0.80（0.41-1.58）；与地西泮相比，1.11（0.70-1.75）。关于总重症监护病房住院时间、总住院时间和通气支持需求的数据存在冲突，由于各个试验的方法学差异，无法进行结果汇总。需要更多的对照试验来评估硫酸镁对减少自主神经不稳定、痉挛、重症监护和住院时间以及机械通气需求的影响。
