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[碳化学:药物化学方面及研究前景]

[Carbonology: pharmacochemical aspect and research prospects].

作者信息

Chekman I S, Syrova H O, Nebesna T Iu, Shapoval L H, Shapoval O V

出版信息

Lik Sprava. 2012 Jan-Mar(1-2):3-12.

Abstract

The paper is devoted to the new direction of science - carbonology. Carbon is the base of organic compounds. Compounds of carbon with metals are known. The article gives a brief description of the three allotropic forms of carbon (soot, graphite, diamond), and various types of hybridization in organic structures, describes the role of biogenic carbon. At the end of the twentieth century new carbon nanostructures were discovered: fullerenes and carbon nanotubes. Scientists all over the world study physical, chemical, pharmacological and toxicological properties of the allotropes of carbon structures, which are promising for nanochemistry, nanopharmacology and nanotoxicology. The main characteristics of fullerenes are the high electrical conductivity, antiviral, antioxidant properties and possible use for targeted drug delivery. Carbon nanotubes have strong adsorption properties, high electrical conductivity, strength, are used for targeted drug delivery and the production of biosensors. In order to introduce carbon nanoparticles in the practical medicine it is necessary to intensify research to biosafety.

摘要

本文致力于科学的新方向——碳学。碳是有机化合物的基础。碳与金属的化合物是已知的。文章简要描述了碳的三种同素异形体(烟灰、石墨、金刚石),以及有机结构中的各种杂化类型,阐述了生物源碳的作用。20世纪末发现了新的碳纳米结构:富勒烯和碳纳米管。全世界的科学家都在研究碳结构同素异形体的物理、化学、药理和毒理学性质,这些性质对纳米化学、纳米药理学和纳米毒理学很有前景。富勒烯的主要特性是高导电性、抗病毒、抗氧化特性以及在靶向药物递送方面的可能用途。碳纳米管具有很强的吸附性能、高导电性、强度,用于靶向药物递送和生物传感器的生产。为了将碳纳米颗粒引入实际医学,有必要加强对生物安全性的研究。

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