胫前大疱性表皮松解症：一例报告。
Pretibial epidermolysis bullosa: report of a case.
作者信息
Lichtenwald D J, Hanna W, Sauder D N, Jakubovic H R, Rosenthal D
机构信息
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
出版信息
J Am Acad Dermatol. 1990 Feb;22(2 Pt 2):346-50. doi: 10.1016/0190-9622(90)70045-j.
Pretibial epidermolysis bullosa is a rare variant of hereditary epidermolysis bullosa that is characterized by the delayed onset of a blistering eruption limited to the pretibial area. We present a case in a 48-year-old woman. Immunofluorescence mapping demonstrated blister formation below the basement membrane. This was confirmed by ultrastructural investigations that also revealed rudimentary anchoring fibrils similar to those described in the dominant dystrophic forms of epidermolysis bullosa.
胫前大疱性表皮松解症是遗传性大疱性表皮松解症的一种罕见变体，其特征为水疱性皮疹起病延迟，且局限于胫前区域。我们报告一例48岁女性患者。免疫荧光定位显示水疱在基底膜下方形成。超微结构研究证实了这一点，该研究还发现了与显性营养不良型大疱性表皮松解症中所描述的类似的原始锚原纤维。
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