Department of Internal Medicine, Division of Endocrinology and Metabolism, Buddhist Tzu Chi General Hospital, Taipei, Taiwan.
Aging Male. 2012 Dec;15(4):227-32. doi: 10.3109/13685538.2012.720742. Epub 2012 Oct 5.
Hypertension and prehypertension are correlated with future cardiovascular disease (CVD) and diabetes. Whether these harmful effects of the blood pressure (BP) could be found in normotensive is of interest.
In this cross-sectional study, totally 2388 normotensive older men aged 65-80 years undergoing routine health examinations were enrolled. To eliminate the influence of age on BP, subjects were initially grouped in each age stratum. Then in each age-stratum, subjects were further grouped into low, middle and high-tertile systolic BP (SBP) subgroups. Finally, all the low-tertile subgroups in each age stratum were gathered to form Group-1. Similarly, Group-2 (middle-tertile) and Group-3 (high-tertile) were also created. Metabolic syndrome (MetS) was regarded as having risks for future CVD and diabetes.
Age, waist circumstance (WC), fasting plasma glucose (FPG) and log triglyceride (TG) were independently and significantly correlated with SBP by multiple linear regression analysis. On the other hand, logistic regression showed that Group-3 had significant higher odds ratios (ORs) for having abnormal WC, FPG and TG. In addition, Group-3 presented a 1.55-fold OR (p < 0.001) for having MetS than Group-1.
In normotensive older men, the risk for having MetS was significantly associated with higher SBP. Primary prevention of hypertension should be stressed.
高血压和血压前期与未来的心血管疾病（CVD）和糖尿病相关。在血压正常的人群中是否也存在这些血压升高的有害影响，这一点很值得关注。
在这项横断面研究中，共纳入了 2388 名年龄在 65-80 岁、接受常规健康检查的血压正常的老年男性。为了消除年龄对血压的影响，首先将受试者按每个年龄组分组。然后，在每个年龄组中，进一步将受试者分为低、中、高三分位收缩压（SBP）亚组。最后，将每个年龄组中的所有低三分位亚组聚集在一起组成第 1 组。同样，也创建了第 2 组（中三分位）和第 3 组（高三分位）。代谢综合征（MetS）被认为是未来 CVD 和糖尿病的危险因素。
多元线性回归分析显示，年龄、腰围（WC）、空腹血糖（FPG）和对数甘油三酯（TG）与 SBP 独立且显著相关。另一方面，逻辑回归显示，第 3 组的 WC、FPG 和 TG 异常的可能性显著高于第 1 组。此外，第 3 组发生 MetS 的比值比（OR）为 1.55（p < 0.001），明显高于第 1 组。
在血压正常的老年男性中，MetS 的风险与较高的 SBP 显著相关。应强调高血压的一级预防。
