Internal Medicine A, Groupe Hospitalier Lariboisière-Fernand Widal-Saint Louis, APHP, Université Paris VII, Paris, France.
HIV Med. 2013 May;14(5):311-5. doi: 10.1111/j.1468-1293.2012.01052.x. Epub 2012 Oct 4.
Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals.
We analysed a clinical cohort of HIV-infected patients who initiated ART between June 2003 and December 2006 and maintained stable CPE scores. Patients were evaluated with a short neuropsychological battery. Using linear regression, we examined the relationship between results of cognitive tests and CPE scores in all patients.
Patients were divided into three similarly sized groups (CPE ≤ 1, CPE between 1.5 and 2.5, and CPE ≥ 2.5). We found that ART with high CPE scores was associated with poorer executive performances in HIV-1-infected patients.
These results suggest that cognitive performance in treated HIV-infected patients could be influenced by ART.
既往针对 HIV 感染者的研究对 ART 对认知的影响得出了相互矛盾的结果。我们的目的是调查具有稳定的中枢神经系统穿透效果（CPE）评分的多年 ART 对 HIV 感染者神经心理表现的影响。
我们分析了 2003 年 6 月至 2006 年 12 月间开始 ART 并维持稳定 CPE 评分的 HIV 感染患者的临床队列。患者接受了简短的神经心理测试。我们使用线性回归分析了所有患者认知测试结果与 CPE 评分之间的关系。
患者被分为三组，CPE 值分别为≤1、1.5-2.5 和≥2.5。我们发现，高 CPE 值的 ART 与 HIV-1 感染者的执行功能较差有关。
这些结果表明，接受治疗的 HIV 感染者的认知表现可能受到 ART 的影响。
