Discipline of Psychology, University of Exeter, Exeter, UK.
Neuropsychologia. 2012 Dec;50(14):3528-41. doi: 10.1016/j.neuropsychologia.2012.09.027. Epub 2012 Oct 2.
Transient epileptic amnesia (TEA) is a recently recognized form of temporal lobe epilepsy which is often associated with persistent interictal impairment of autobiographical memory. We used fMRI to investigate the neural basis of this deficit. Eleven patients with TEA, who had no significant deficits on standard tests of anterograde memory, and 17 age and IQ matched healthy controls retrieved memories from across the lifespan. Both groups engaged the autobiographical memory network, but activation in patients was less extensive than in controls. Direct comparison revealed hypoactivation of regions in the right hemisphere. Specifically, patients showed reduced activation of the posterior parahippocampal gyrus (pPHG), especially for mid-life and recent memories, with decreased engagement of the right temporoparietal junction and the cerebellum. In addition, we found reduced effective connectivity in patients between the right pPHG and the right middle temporal gyrus. Our results are consistent with other evidence that TEA is a syndrome of medial temporal lobe epilepsy and indicate that it affects the function and connectivity of regions within the autobiographical memory network.
短暂性癫痫性遗忘症（TEA）是一种最近被认识到的颞叶癫痫形式，常伴有持续性自传体记忆损伤。我们使用 fMRI 来研究这一缺陷的神经基础。11 名 TEA 患者在标准的顺行记忆测试中没有明显缺陷，17 名年龄和智商匹配的健康对照者从整个生命周期中检索记忆。两组均激活了自传体记忆网络，但患者的激活范围不如对照组广泛。直接比较显示，右侧半球的激活减少。具体来说，患者的后内嗅皮层（pPHG）活动减少，特别是对中年和近期记忆，右侧颞顶联合区和小脑的参与减少。此外，我们发现患者右侧 pPHG 与右侧颞中回之间的有效连接减少。我们的结果与其他证据一致，即 TEA 是内侧颞叶癫痫的综合征，并表明它影响自传体记忆网络内区域的功能和连接。
