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低剂量组织型纤溶酶原激活剂长时间输注对一名患有急性肺栓塞和主肺动脉血栓的九旬患者的疗效。

Effectiveness of low-dose prolonged infusion of tissue plasminogen activator in a nonagenarian patient with acute pulmonary embolism and main pulmonary artery thrombus.

作者信息

Yildiz Mustafa, Karakoyun Suleyman, Acar Rezzan Deniz, Ozkan Mehmet

机构信息

Department of Cardiology, Kartal Koşuyolu Yüksek Ihtisas Educational and Research Hospital, Istanbul, Turkey.

出版信息

Blood Coagul Fibrinolysis. 2013 Jan;24(1):95-6. doi: 10.1097/MBC.0b013e328359759c.

DOI:10.1097/MBC.0b013e328359759c
PMID:23037320
Abstract

Acute pulmonary embolism is an important emergency disease which frequently results in life-threatening complication. Systemic fibrinolysis is recommended as standard, first-line therapy in patients with massive pulmonary embolism. In the case described in this report, a 95-year-old woman was treated with low-dose prolonged infusion of tissue plasminogen activator for acute pulmonary embolism and mobile thrombus in the main pulmonary artery and right pulmonary artery. On the basis of echocardiographic findings, acute thrombolysis with low-dose prolonged infusion of tissue plasminogen activator was performed resulting in hemodynamic stabilization of the patient and complete resolution of the pulmonary artery thrombus.

摘要

急性肺栓塞是一种重要的急症,常导致危及生命的并发症。对于大面积肺栓塞患者,推荐全身纤溶治疗作为标准的一线治疗方法。在本报告所述病例中,一名95岁女性因急性肺栓塞及主肺动脉和右肺动脉内的活动血栓,接受了低剂量组织纤溶酶原激活剂长时间输注治疗。根据超声心动图检查结果,对患者进行了低剂量组织纤溶酶原激活剂长时间输注的急性溶栓治疗,结果患者血流动力学稳定,肺动脉血栓完全溶解。

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Reduced-Dose Systemic Fibrinolysis in Massive Pulmonary Embolism: A Pilot Study.大剂量肺栓塞中低剂量全身纤溶治疗:一项初步研究。
Clin Exp Emerg Med. 2023 Sep;10(3):280-286. doi: 10.15441/ceem.23.015. Epub 2023 May 15.
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Expression of tissue factor in rabbit pulmonary artery in an acute pulmonary embolism model.
组织因子在急性肺栓塞模型兔肺动脉中的表达。
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