Di Rosa Salvatore, Caramanno Giuseppe, Catalano Calogero, Andò Giuseppe, Innocente Piero, Cutaia Angelo, Carlino Gabriella, Vaccaro Giovanni, Vaccaro Ignazio
U.O. di Cadiologia-UTIC, Ospedale Sun Giovanni de Dio, Agrigento.
G Ital Cardiol (Rome). 2011 Sep;12(9):619-22. doi: 10.1714/926.10177.
Massive pulmonary embolism (PE) is a cardiovascular emergency due to a substantial obstruction of the pulmonary vascular bed, resulting in rapid right heart failure with a potentially fatal outcome.We present the case of a 50-year-old woman with massive PE and recent trans-sphenoid surgery because of pituitary adenoma. An occluding embolus, arising from deep venous thrombosis of the lower limbs, was demonstrated in the right pulmonary artery with selective angiography and treated with selective loco-regional infusion of low-dose tenecteplase. To the best of our knowledge, this is the first case of selective administration of low-dose tenecteplase in the pulmonary artery with successful resolution of PE without the need for adjunctive interventional procedures.
大面积肺栓塞（PE）是一种心血管急症，由于肺血管床严重阻塞，导致快速右心衰竭，具有潜在致命后果。我们报告一例50岁女性，患有大面积肺栓塞，近期因垂体腺瘤接受经蝶窦手术。选择性血管造影显示右肺动脉有一个由下肢深静脉血栓形成引起的阻塞性栓子，并采用低剂量替奈普酶选择性局部灌注进行治疗。据我们所知，这是首例在肺动脉中选择性给予低剂量替奈普酶成功解决肺栓塞且无需辅助介入程序的病例。
