Wang Zhaohui, Ha Seunghan, Kim Kang
Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Opt Express. 2012 Sep 24;20(20):22649-59. doi: 10.1364/OE.20.022649.
A new light illumination scheme to increase imaging depth in photoacoustic (PA) imaging was designed and evaluated by in silico simulations and tested by in vitro experiments. A relatively large portion of the light energy shining into the body of a human reflects off the skin surfaces. Collecting the reflected light and redirecting it onto skin surfaces will increase the effective input energy, resulting in an increase of light penetration depth for the same light source. Its performance in PA imaging was evaluated using a finite element (FE)-based numerical simulation model composed of four modules. In the in vitro experiments with the light catcher, PA image of multiple targets at different locations exhibited an enhancement both in uniformity and in depth of the light illumination.
设计了一种用于增加光声（PA）成像中成像深度的新型光照方案，并通过计算机模拟进行评估，通过体外实验进行测试。照射到人体的相当一部分光能从皮肤表面反射回来。收集反射光并将其重新导向皮肤表面将增加有效输入能量，从而在使用相同光源的情况下增加光穿透深度。使用由四个模块组成的基于有限元（FE）的数值模拟模型评估其在PA成像中的性能。在使用光捕获器的体外实验中，不同位置多个目标的PA图像在光照均匀性和深度方面均表现出增强。
