Mozaffari-Khosravi Hassan, Hesabgar Hamideh-al-Sadat, Owlia Mohammad-Bagher, Hadinedoushan Hossein, Barzegar Kazem, Fllahzadeh Mohammad Hossein
Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Diet Suppl. 2012 Dec;9(4):262-71. doi: 10.3109/19390211.2012.726703. Epub 2012 Oct 8.
Menopause is one of the important causes of osteoporosis which results from estrogen deficiency. In addition, some clinical and experimental evidence indicates that there is an association between increasing pro-inflammatory cytokine activity and postmenopausal bone loss. The purpose of this study was to determine the effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women.
The present study was a double-blind randomized controlled clinical trial in Yazd conducted during November 2009 until July 2010. The sample included 44 postmenopausal osteoporotic women who were randomly assigned into two groups: the garlic group (GG) and the placebo group (PG). Participants in GG took two garlic tablets daily for 1 month and the participants in PG took placebo tablets in the same manner. Serum interlukin-1, interlukin-6, and tumor necrosis factor alpha (TNF-α) were measured using the ELISA method before and after the intervention. Also, 24-hour dietary recall was recorded for estimation of daily intake of some nutrients. Data were analyzed using SPSS software.
There was no statistically significant difference between interlukin-1 and interlukin-6 in the two groups before and after the intervention. The mean of TNF-α did not show any statistically significant difference between the two groups before and after the intervention, but it was significantly reduced by about 47% (from 31.14±50.53 to 19.33±22.19 ng/ml, P-value = 0.05) in GG after the intervention, However, no significant difference was seen in PG.
The present study produced some evidence for an immunomodulatory effect of garlic, as well as the modulation of cytokine production.
绝经是雌激素缺乏导致骨质疏松的重要原因之一。此外，一些临床和实验证据表明，促炎细胞因子活性增加与绝经后骨质流失之间存在关联。本研究的目的是确定大蒜片对绝经后骨质疏松女性促炎细胞因子的影响。
本研究是于2009年11月至2010年7月在亚兹德进行的一项双盲随机对照临床试验。样本包括44名绝经后骨质疏松女性，她们被随机分为两组：大蒜组（GG）和安慰剂组（PG）。GG组的参与者每天服用两片大蒜片，持续1个月，PG组的参与者以相同方式服用安慰剂片。在干预前后使用酶联免疫吸附测定法（ELISA）测量血清白细胞介素-1、白细胞介素-6和肿瘤坏死因子α（TNF-α）。此外，记录24小时饮食回忆以估计某些营养素的每日摄入量。使用SPSS软件分析数据。
两组在干预前后白细胞介素-1和白细胞介素-6之间无统计学显著差异。两组在干预前后TNF-α的平均值均未显示出任何统计学显著差异，但干预后GG组的TNF-α显著降低了约47%（从31.14±50.53降至19.33±22.19 ng/ml，P值 = 0.05），而PG组未见显著差异。
本研究为大蒜的免疫调节作用以及细胞因子产生的调节提供了一些证据。
