Ahmadian Fereshte, Mozaffari-Khosravi Hassan, Azaraein Mohammad Hossein, Faraji Reza, Zavar-Reza Javad
M.Sc., Department of Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Ph.D., Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Electron Physician. 2017 Nov 25;9(11):5670-5675. doi: 10.19082/5670. eCollection 2017 Nov.
Osteoporosis (OP) is one of the most prevalent metabolic bone diseases at higher ages, especially in postmenopausal women.
To determine the effect of consumption of garlic tablet on proteins oxidation biomarkers in postmenopausal osteoporotic women.
The present study was a double-blind randomized controlled clinical trial that included 42 postmenopausal women in Yazd during 2014-2015. Osteoporotic women were randomly assigned into two groups: the garlic group (GG) and the placebo group (PG). Participants in GG took two garlic tablets daily for 1 month and the participants in PG took placebo tablets in the same manner. After 30 days, the plasma level of carbonyl groups (PCO), total antioxidant capacity (TAC), and advanced oxidation protein products (AOPPs) were assessed by spectrophotometric assays. Also, Malondialdehyde (MDA) content was measured according to the procedure of Thiobarbituric Acid (TBA). Data were analyzed by SPSS version 18, using paired-samples t-test, independent-samples t-test, Wilcoxon, and Mann-Whitney U test.
This study showed that garlic tablets had decreased PCO plasma levels (47.37±5.98 vs. 19.62±3.40 nM, p≤0.001, before and after the study, respectively), AOPPs (738.95±151.86 vs. 585.12±209.99 μM, p≤0.008, before and after the study, respectively), and increased TAC (11.34±10.80 vs. 47.93±17.80, p≤0.001, before and after the study, respectively). The parameters in placebo groups showed no significant differences before and after the study, respectively. The levels of MDA before taking the drug in comparison to before Garlic group was also reduced (1.30±1.04 vs. 0.92±0.81 μM, p=0.01, before and after the study, respectively).
The role of oxidative stress in the pathophysiology of many diseases such as osteoporosis has been demonstrated. The present study showed that garlic consumption can reduce the oxidative stress.
The protocol of trial was registered at the Iranian clinical trial register (www.irct.ir) with ID: IRCT138811183273N1.
This study funded by Shahid Sadoughi University of Medical Sciences (Yazd, Iran).
骨质疏松症（OP）是老年人群中最常见的代谢性骨病之一，尤其是在绝经后女性中。
确定服用大蒜片对绝经后骨质疏松症女性蛋白质氧化生物标志物的影响。
本研究为双盲随机对照临床试验，于2014 - 2015年纳入了亚兹德的42名绝经后女性。骨质疏松症女性被随机分为两组：大蒜组（GG）和安慰剂组（PG）。GG组参与者每天服用两片大蒜片，持续1个月，PG组参与者以相同方式服用安慰剂片。30天后，通过分光光度法测定血浆羰基（PCO）水平、总抗氧化能力（TAC）和晚期氧化蛋白产物（AOPPs）。此外，根据硫代巴比妥酸（TBA）程序测量丙二醛（MDA）含量。数据采用SPSS 18版进行分析，使用配对样本t检验、独立样本t检验、Wilcoxon检验和Mann - Whitney U检验。
本研究表明，大蒜片可降低血浆PCO水平（研究前后分别为47.37±5.98 vs. 19.62±3.40 nM，p≤0.001）、AOPPs（研究前后分别为738.95±151.86 vs. 585.12±209.99 μM，p≤0.008），并提高TAC（研究前后分别为11.34±10.80 vs. 47.93±17.80，p≤0.001）。安慰剂组的参数在研究前后分别无显著差异。与服药前相比，大蒜组服药前的MDA水平也有所降低（研究前后分别为1.30±1.04 vs. 0.92±0.81 μM，p = 0.01）。
氧化应激在许多疾病如骨质疏松症的病理生理过程中的作用已得到证实。本研究表明，食用大蒜可减轻氧化应激。
该试验方案已在伊朗临床试验注册中心（www.irct.ir）注册，注册号：IRCT138811183273N1。
本研究由设拉子沙希德萨杜基医科大学（伊朗亚兹德）资助。
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