Acquavella J F, Owen C V
Exxon Biomedical Sciences, Inc., East Millstone, NJ 08875-2350.
J Occup Med. 1990 Feb;32(2):127-30.
Our recent study reported a colorectal cancer excess among workers involved in the manufacture of polypropylene. To follow up on this finding, we initiated a study of colorectal cancer incidence among polypropylene pilot plant workers within the same company. The purpose of this investigation was to determine whether colorectal cancer incidence was elevated among workers who may have had exposures similar to those experienced on the commercial production unit. The study population included 183 employees who worked at least 6 months on either of two pilot plants. Overall, there were three observed colorectal cases v. 3.3 expected (standardized incidence ratio = 0.9, 90% confidence interval 0.3 to 2.3). Analyses for the process, mechanic, and laboratory subgroup showed rates consistent with expected values (3 observed, 2.8 expected; standardized incidence ratio = 1.1, 90% confidence interval 0.3 to 2.8). Analyses by duration of employment and latency did not show patterns consistent with the colorectal cancer excess previously reported. The likelihood of lower or different exposures on the pilot plant than would be found on commercial production units is discussed along with the need for studies of workers in other polypropylene manufacturing environments.
我们最近的研究报告称，参与聚丙烯生产的工人患结直肠癌的风险更高。为跟进这一发现，我们对同一家公司聚丙烯中试工厂的工人开展了结直肠癌发病率研究。本次调查的目的是确定在可能接触过与商业生产部门类似物质的工人中，结直肠癌发病率是否有所升高。研究对象包括在两个中试工厂中的任何一个工作至少6个月的183名员工。总体而言，观察到3例结直肠癌病例，预期为3.3例（标准化发病率 = 0.9，90%置信区间为0.3至2.3）。对工艺、机械和实验室亚组的分析显示发病率与预期值一致（观察到3例，预期为2.8例；标准化发病率 = 1.1，90%置信区间为0.3至2.8）。按就业时长和潜伏期进行的分析未显示出与先前报告的结直肠癌超额风险相符的模式。文中讨论了中试工厂接触物质低于或不同于商业生产部门的可能性，以及对其他聚丙烯生产环境中的工人进行研究的必要性。
