Lewis R J, Schnatter A R, Lerman S E
Exxon Biomedical Sciences, Inc, East Millstone, New Jersey 08875-2350.
J Occup Med. 1994 Jun;36(6):652-9.
This study updates an earlier investigation that found a sixfold excess incidence of colorectal cancer among polypropylene workers for the period January 1960 to September 1985. The study cohort comprised 412 male workers with at least 6 months employment and 10 years latency. For the extended follow-up period (October 1985 to May 1992), the standardized incidence ratio (SIR) based on state comparison rates was slightly elevated and not statistically significant (SIR = 1.5, 95% confidence interval [CI] = 0.5 to 3.5). A 2.3-fold excess was observed among process workers (95% CI = 0.3 to 8.2), but this was based on only two cases. Risk among process/mechanical workers was greater for short-term workers (< 10 years, SIR = 3.2, 95% CI = 0.7 to 9.2) compared with longer-term workers (> or = 10 years, SIR = 0.7, 95% CI = 0.02 to 4.0). Overall, the update findings do not suggest an occupationally related risk. Possible influences of company-sponsored colorectal cancer screening, the polyolefin unit shutdown, and other factors are discussed.
本研究更新了一项早期调查，该调查发现在1960年1月至1985年9月期间，聚丙烯工人患结直肠癌的发病率高出六倍。研究队列包括412名男性工人，他们至少工作了6个月，潜伏期为10年。在延长的随访期（1985年10月至1992年5月），基于州比较率的标准化发病率（SIR）略有升高，但无统计学意义（SIR = 1.5，95%置信区间[CI] = 0.5至3.5）。在生产工人中观察到高出2.3倍（95%CI = 0.3至8.2），但这仅基于两例病例。与长期工人（≥10年，SIR = 0.7，95%CI = 0.02至4.0）相比，短期工人（<10年）在生产/机械工人中的风险更高（SIR = 3.2，95%CI = 0.7至9.2）。总体而言，更新后的结果未表明存在职业相关风险。讨论了公司赞助的结直肠癌筛查、聚烯烃装置停产及其他因素的可能影响。
