University of Edinburgh and London School of Hygiene and Tropical Medicine, Edinburgh, UK.
Contraception. 2013 Mar;87(3):309-13. doi: 10.1016/j.contraception.2012.08.027. Epub 2012 Oct 4.
Emergency contraception (EC) is widely used to prevent unwanted pregnancy. This review considers the safety and efficacy of three commonly used methods -- levonorgestrel (LNG-EC), ulipristal acetate (UPA) and the copper intrauterine device. All are extremely safe, and side effects are minimal. Concerns about increased risks of ectopic pregnancy after EC use have proved unfounded, and possible teratogenic effects seem unlikely. Although the true effectiveness of EC is impossible to estimate, recent research suggests that LNG-EC prevents around 50% of expected pregnancies in women using the method within 72 h of intercourse, whereas UPA appeared to prevent almost two thirds of pregnancies. Emergency intrauterine device insertion probably prevents over 95% of pregnancies. However, although improved accessibility of EC has clearly led to increased use, it does not appear to have had any public health benefit in reducing unintended pregnancy rates. Most of the data on sexual behavior following improved access to EC do not show any detrimental effect on subsequent use of other more effective methods of contraception or on the incidence of unintended pregnancy or sexually transmitted infection. However, unless these other methods of contraception are also made easily available from pharmacies, improved access to EC risks unlinking its use with use of subsequent ongoing contraception.
紧急避孕(EC)被广泛用于预防意外怀孕。本综述考虑了三种常用方法——左炔诺孕酮(LNG-EC)、依托孕烯(UPA)和铜宫内节育器——的安全性和有效性。所有这些方法都非常安全,副作用极小。关于 EC 使用后异位妊娠风险增加的担忧被证明是没有根据的,可能的致畸作用似乎不太可能。尽管 EC 的真实效果难以估计,但最近的研究表明,LNG-EC 在性交后 72 小时内使用,可预防约 50%的预期妊娠,而 UPA 似乎可预防近三分之二的妊娠。紧急宫内节育器放置可能可预防超过 95%的妊娠。然而,尽管 EC 可及性的提高显然导致了其使用的增加,但它似乎并没有对降低意外怀孕率产生任何公共卫生效益。关于改善 EC 可及性后性行为的大部分数据并未显示对随后使用其他更有效的避孕方法或意外怀孕或性传播感染的发生率有任何不利影响。然而,除非从药店也可轻松获得这些其他避孕方法,否则改善 EC 的可及性可能会导致其使用与随后持续使用避孕方法脱钩。