Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Cell Stem Cell. 2012 Oct 5;11(4):461-9. doi: 10.1016/j.stem.2012.09.003.
Asymmetric cell division (ACD) produces two daughter cells with distinct fates or characteristics. Many adult stem cells use ACD as a means of maintaining stem cell number and thus tissue homeostasis. Here, we review recent progress on ACD, discussing conservation between stem and non-stem cell systems, molecular mechanisms, and the biological meaning of ACD.
不对称细胞分裂（ACD）产生具有不同命运或特征的两个子细胞。许多成体干细胞使用 ACD 作为维持干细胞数量从而维持组织内稳态的手段。在这里，我们综述了 ACD 的最新进展，讨论了干细胞和非干细胞系统之间的保守性、分子机制以及 ACD 的生物学意义。
