Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich, 8093, Switzerland.
Eur J Immunol. 2023 Dec;53(12):e2250225. doi: 10.1002/eji.202250225. Epub 2023 Feb 27.
Establishment of cellular diversity is a basic requirement for the development of multicellular organisms. Cellular diversification can be induced by asymmetric cell division (ACD), during which the emerging two daughter cells unequally inherit lineage specific cargo (including transcription factors, receptors for specific signaling inputs, metabolic platforms, and possibly different epigenetic landscapes), resulting in two daughter cells endowed with different fates. While ACD is strongly involved in lineage choices in mammalian stem cells, its role in fate diversification in lineage committed cell subsets that still exhibit plastic potential, such as T-cells, is currently investigated. In this review, we focus predominantly on the role of ACD in fate diversification of CD8 T-cells. Further, we discuss the impact of differential T-cell receptor stimulation strengths and differentiation history on ACD-mediated fate diversification and highlight a particular importance of ACD in the development of memory CD8 T-cells upon high-affinity stimulation conditions.
建立细胞多样性是多细胞生物发育的基本要求。细胞多样化可以通过不对称细胞分裂（ACD）来诱导，在此过程中，新生成的两个子细胞不均等地继承谱系特异性货物（包括转录因子、特定信号输入的受体、代谢平台，以及可能不同的表观遗传景观），导致两个子细胞具有不同的命运。虽然 ACD 在哺乳动物干细胞的谱系选择中起着重要作用，但它在仍然表现出可塑性的谱系定向细胞亚群（如 T 细胞）中的命运多样化中的作用目前正在研究中。在这篇综述中，我们主要关注 ACD 在 CD8 T 细胞命运多样化中的作用。此外，我们讨论了不同的 T 细胞受体刺激强度和分化历史对 ACD 介导的命运多样化的影响，并强调了 ACD 在高亲和力刺激条件下记忆 CD8 T 细胞发育中的重要性。
