Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA.
J Am Coll Cardiol. 2012 Oct 30;60(18):1817-24. doi: 10.1016/j.jacc.2012.06.050. Epub 2012 Oct 3.
The aim of this study was to evaluate the impact of reductions in statin and clopidogrel copayments on cardiovascular resource utilization, major coronary events, and insurer spending.
Copayments are widely used to contain health spending but cause patients to reduce their use of essential cardiovascular medications. Reducing copayments for post-myocardial infarction secondary prevention has beneficial effects, but the impact of this strategy for lower risk patients and other drugs remains unclear.
An evaluation was conducted of health care spending and resource use by a large self-insured employer that reduced statin copayments for patients with diabetes or vascular disease and reduced clopidogrel copayments for all patients prescribed this drug. Eligible individuals in the intervention company (n = 3,513) were compared with a control group from other companies without such a policy (n = 49,803). Analyses were performed using segmented regression models with generalized estimating equations.
Lowering copayments was associated with significant reductions in rates of physician visits (relative change: statin users 0.80; 95% confidence interval [CI]: 0.57 to 0.98; clopidogrel users: 0.87; 95% CI: 0.59 to 0.96) and hospitalizations and emergency department admissions (relative change: statin users 0.90; 95% CI: 0.80 to 0.92; clopidogrel users: 0.89; 95% CI: 0.74 to 0.90) although not major coronary events. Patient out-of-pocket spending for drugs and other medical services decreased (relative change: statin users 0.79; 95% CI: 0.75 to 0.83; clopidogrel users 0.74; 95% CI: 0.66 to 0.82). Providing more generous coverage did not increase overall spending (relative change: statin users 1.03; 95% CI: 0.97 to 1.09; clopidogrel users 0.94; 95% CI: 0.87 to 1.03).
Lowering copayments for statins and clopidogrel was associated with reductions in health care resource use and patient out-of-pocket spending. The policy appeared cost neutral with respect to overall health spending.
本研究旨在评估他汀类药物和氯吡格雷共同支付额降低对心血管资源利用、主要冠状动脉事件和保险公司支出的影响。
共同支付额被广泛用于控制医疗支出,但会导致患者减少对基本心血管药物的使用。降低心肌梗死后二级预防的共同支付额有有益的效果,但对于风险较低的患者和其他药物,这种策略的影响尚不清楚。
对一家大型自我保险雇主的医疗保健支出和资源利用情况进行了评估,该雇主降低了患有糖尿病或血管疾病的患者的他汀类药物共同支付额,并降低了所有开氯吡格雷药物的患者的氯吡格雷共同支付额。在干预公司(n=3513)中的合格个体与没有此类政策的其他公司(n=49803)的对照组进行了比较。使用广义估计方程的分段回归模型进行了分析。
降低共同支付额与医生就诊率显著降低相关(相对变化:他汀类药物使用者 0.80;95%置信区间[CI]:0.57 至 0.98;氯吡格雷使用者:0.87;95%CI:0.59 至 0.96)和住院率及急诊就诊率(相对变化:他汀类药物使用者 0.90;95%CI:0.80 至 0.92;氯吡格雷使用者:0.89;95%CI:0.74 至 0.90),尽管与主要冠状动脉事件无关。患者的药物和其他医疗服务自付费用减少(相对变化:他汀类药物使用者 0.79;95%CI:0.75 至 0.83;氯吡格雷使用者 0.74;95%CI:0.66 至 0.82)。提供更慷慨的覆盖范围并没有增加总支出(相对变化:他汀类药物使用者 1.03;95%CI:0.97 至 1.09;氯吡格雷使用者 0.94;95%CI:0.87 至 1.03)。
降低他汀类药物和氯吡格雷的共同支付额与医疗资源利用和患者自付费用的减少有关。就总医疗支出而言,该政策似乎没有成本中性。