Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan.
Am J Cardiol. 2013 Jan 1;111(1):6-11. doi: 10.1016/j.amjcard.2012.08.038. Epub 2012 Oct 2.
A low ratio of n-3 to n-6 polyunsaturated fatty acids has been associated with cardiovascular events. However, the effects of this ratio on coronary atherosclerosis have not been fully examined. The purpose of the present study was to evaluate the correlations between the n-3 to n-6 polyunsaturated fatty acid ratio and coronary atherosclerosis. Coronary atherosclerosis in nonculprit lesions in the percutaneous coronary intervention vessel was evaluated using virtual histology intravascular ultrasound in 101 patients at the time of percutaneous coronary intervention and 8 months after statin therapy. Forty-six patients (46%) showed atheroma progression and the remaining 55 patients (54%) showed atheroma regression at 8-month follow-up. Significant negative correlations were observed between percentage change in plaque volume and change in the eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio (r = -0.190, p = 0.05), docosahexaenoic acid (DHA)/AA ratio (r = -0.231, p = 0.02), and EPA+DHA/AA ratio (r = -0.240, p = 0.02). Furthermore, percentage change in the fibrous component volume was negatively and significantly correlated with change in the EPA/AA ratio (r = -0.206, p = 0.04) and EPA+DHA/AA ratio (r = -0.217, p = 0.03). Multivariate regression analysis showed that change in the EPA+DHA/AA ratio was a significant predictor of percentage change in plaque volume and fibrous component volume (β = -0.221, p = 0.02, and β = -0.200, p = 0.04, respectively). In conclusion, decreases in serum n-3 to n-6 polyunsaturated fatty acid ratios are associated with progression in coronary atherosclerosis evaluated using virtual histology intravascular ultrasound in statin-treated patients with coronary artery disease.
n-3 与 n-6 多不饱和脂肪酸比值低与心血管事件有关。然而，这种比值对冠状动脉粥样硬化的影响尚未完全研究。本研究旨在评估 n-3 与 n-6 多不饱和脂肪酸比值与冠状动脉粥样硬化之间的相关性。在经皮冠状动脉介入治疗时和他汀类药物治疗 8 个月后，通过虚拟组织学血管内超声评估经皮冠状动脉介入治疗血管中的非罪犯病变中的冠状动脉粥样硬化。在 8 个月的随访中，46 例患者（46%）出现动脉粥样硬化进展，其余 55 例患者（54%）出现动脉粥样硬化消退。斑块体积百分比变化与二十碳五烯酸（EPA）/花生四烯酸（AA）比值（r = -0.190，p = 0.05）、二十二碳六烯酸（DHA）/AA 比值（r = -0.231，p = 0.02）和 EPA+DHA/AA 比值（r = -0.240，p = 0.02）呈显著负相关。此外，纤维成分体积百分比变化与 EPA/AA 比值（r = -0.206，p = 0.04）和 EPA+DHA/AA 比值（r = -0.217，p = 0.03）呈显著负相关。多元回归分析显示，EPA+DHA/AA 比值的变化是斑块体积和纤维成分体积百分比变化的显著预测因子（β = -0.221，p = 0.02，β = -0.200，p = 0.04）。总之，血清 n-3 与 n-6 多不饱和脂肪酸比值的降低与他汀类药物治疗的冠心病患者冠状动脉粥样硬化的进展有关，通过虚拟组织学血管内超声评估。
