Lovell F A
Department of Radiology, University Medical Center, Jackson, MS.
J Miss State Med Assoc. 1990 Jan;31(1):4-6.
This case was a typical presentation for Wegener's granulomatosis with respect to the pulmonary and renal findings. Over the course of the past ten years this patient has done relatively well with only two major exacerbations requiring hospitalization. His renal function has apparently not been compromised to date. The finding of limited or no significant upper respiratory involvement is interesting in this case and is rather atypical for this disease. This may well represent a limited variant of Wegener's granulomatosis or possibly an excellent response of the Wegener's syndrome to cytotoxic chemotherapy. Finally, this case illustrates how appropriate clinical and pharmacological management has greatly improved the morbidity and mortality of this once uniformly fatal disease.
就肺部和肾脏表现而言，该病例是韦格纳肉芽肿的典型表现。在过去十年中，该患者情况相对良好，仅出现两次需要住院治疗的严重病情加重。迄今为止，他的肾功能显然未受损害。该病例中发现上呼吸道受累有限或无明显受累很有意思，对于这种疾病来说相当不典型。这很可能代表韦格纳肉芽肿的一种局限性变体，或者可能是韦格纳综合征对细胞毒性化疗的良好反应。最后，该病例说明了恰当的临床和药物治疗如何极大地改善了这种曾经无一例外会致命的疾病的发病率和死亡率。
