抑郁症。

Depression.

机构信息

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8589, USA.

出版信息

Child Adolesc Psychiatr Clin N Am. 2012 Oct;21(4):807-29. doi: 10.1016/j.chc.2012.07.002.

DOI:10.1016/j.chc.2012.07.002

Abstract

This article reviews the assessment and treatment for depression in children and adolescents, emphasizing the implementation of evidence-based treatments into clinical care. Past trials of antidepressant medications are reviewed, as well as the clinical use of antidepressants and pharmacologic strategies for refractory illness or in the context of comorbid conditions. Clinicians who treat youth now have a body of empiric research to help guide treatment decisions; however, personalized treatment based on associated symptoms, comorbid conditions, contextual factors, and psychiatric history is essential. Further research is needed in the pharmacologic treatment of depressed youth, including expanding the study of non-SSRI antidepressants, augmentation and adjunctive strategies, and treatment in patients with comorbid conditions.

摘要

本文回顾了儿童和青少年抑郁症的评估和治疗，强调将循证治疗方法应用于临床护理中。本文回顾了过去抗抑郁药物的试验，以及抗抑郁药物的临床应用和针对难治性疾病或合并症的药物治疗策略。现在，治疗青少年的临床医生有了大量的经验研究来帮助指导治疗决策；然而，基于相关症状、合并症、环境因素和精神病史的个性化治疗是至关重要的。在抗抑郁药物治疗抑郁青少年方面还需要进一步的研究，包括扩大非 SSRI 类抗抑郁药的研究、增效和辅助治疗策略，以及合并症患者的治疗。