Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
Taiwan J Obstet Gynecol. 2012 Sep;51(3):354-8. doi: 10.1016/j.tjog.2012.07.006.
To evaluate the normal range of the fetal nasal bone length (NBL) in Taiwanese women using three-dimensional (3D) ultrasound, and compare the NBL of normal fetuses with Down syndrome to determine its significance in screening for trisomy 21.
A total of 102 consecutive fetuses and another 7 fetuses with trisomy 21, determined by karyotyping at 15-22 weeks' gestation, were evaluated with 3D ultrasound before amniocentesis at Changhua Christian Hospital between November 2003 and April 2004.
The normal range for NBL in the second trimester in the Taiwanese population was investigated, and a linear relationship with gestational age was noted. The NBL increased with advancing gestational age (NBL in cm=0.0264×gestational age in weeks -0.042 (R(2)=0.2416). The median of the biparietal diameter/nasal bone length ratio had a stable value which tended to change minimally between 15 and 22 weeks of gestation. Chromosomally normal fetuses had statistically longer nasal bones than fetuses with Down syndrome (p=0.014).
We present a reference range for 3D ultrasound measurement of the fetal NBL. A short nasal bone at 15 to 22 weeks is associated with a high risk of trisomy 21.
利用三维（3D）超声评估台湾女性胎儿鼻骨长度（NBL）的正常范围，并比较正常胎儿和唐氏综合征胎儿的 NBL，以确定其在筛查 21 三体中的意义。
2003 年 11 月至 2004 年 4 月，在彰化基督教医院，对 102 例连续胎儿和 7 例经核型分析在 15-22 周时诊断为 21 三体的胎儿进行了 3D 超声检查。
研究了台湾人群中胎儿 NBL 的正常范围，并发现其与胎龄之间存在线性关系。NBL 随胎龄的增加而增加（NBL 以厘米计=0.0264×孕周数-0.042（R²=0.2416）。双顶径/鼻骨长度比值的中位数在 15 至 22 周之间变化稳定，趋于最小化。染色体正常的胎儿的鼻骨长度比唐氏综合征胎儿长（p=0.014）。
我们提出了胎儿 NBL 的 3D 超声测量参考范围。15-22 周时鼻骨短与 21 三体风险增加有关。
