异烟肼中毒表现为癫痫发作和代谢性酸中毒。
Isoniazid toxicity presenting as seizures and metabolic acidosis.
作者信息
Watkins R C, Hambrick E L, Benjamin G, Chavda S N
机构信息
Department of Emergency Medicine, Howard University Hospital, Washington, DC 20060.
出版信息
J Natl Med Assoc. 1990 Jan;82(1):57, 62, 64.
Abstract
The presenting signs and symptoms of isoniazid toxicity are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces severe central nervous system symptoms that are rapidly reversed with intravenous administration of pyridoxine.
摘要
本文讨论了异烟肼中毒的临床表现和症状，并回顾了这种代谢性脑病使用维生素B6（吡哆醇）的并发症及处理方法。本研究支持既往研究结果，即摄入超过80毫克/千克体重会产生严重的中枢神经系统症状，静脉注射吡哆醇可迅速逆转这些症状。
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2
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本文引用的文献
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Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.人体内异烟肼的代谢与周围神经炎发生的关系。
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Single high-dose pyridoxine treatment for isoniazid overdose.
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Molecular epidemiology of antibiotic resistance in salmonella from animals and human beings in the United States.美国动物和人类沙门氏菌抗生素耐药性的分子流行病学
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Optimal antidotal dose of activated charcoal.活性炭的最佳解毒剂量。
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Profound acidosis caused by isoniazid ingestion.异烟肼摄入导致的严重酸中毒。
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Treatment of acute isoniazid toxicity.急性异烟肼中毒的治疗。
Am J Hosp Pharm. 1975 Feb;32(2):202-6.
7
Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.异烟肼在结核分枝杆菌中分枝菌酸合成过程中的抑制作用位点。
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