Watkins R C, Hambrick E L, Benjamin G, Chavda S N
Department of Emergency Medicine, Howard University Hospital, Washington, DC 20060.
J Natl Med Assoc. 1990 Jan;82(1):57, 62, 64.
The presenting signs and symptoms of isoniazid toxicity are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces severe central nervous system symptoms that are rapidly reversed with intravenous administration of pyridoxine.
本文讨论了异烟肼中毒的临床表现和症状，并回顾了这种代谢性脑病使用维生素B6（吡哆醇）的并发症及处理方法。本研究支持既往研究结果，即摄入超过80毫克/千克体重会产生严重的中枢神经系统症状，静脉注射吡哆醇可迅速逆转这些症状。
