Brown A, Mallett M, Fiser D, Arnold W C
Pediatr Pharmacol (New York). 1984;4(3):199-202.
Acute toxicity from ingestion of isoniazid (INH) is manifested by coma and seizures unresponsive to conventional therapy. Though small doses of pyridoxine can reverse the seizure activity of acute isoniazid toxicity, large doses of pyridoxine (B6) are needed to completely reverse the symptoms. A case report is presented demonstrating the need for large doses of pyridoxine to reverse the symptoms of isoniazid intoxication and the literature of isoniazid toxicity in the pediatric age group is reviewed.
摄入异烟肼（INH）导致的急性毒性表现为昏迷和惊厥，常规治疗对此无效。虽然小剂量的吡哆醇可以逆转急性异烟肼毒性的惊厥活动，但需要大剂量的吡哆醇（B6）才能完全逆转症状。本文报告了一例病例，表明需要大剂量的吡哆醇来逆转异烟肼中毒的症状，并对儿科年龄组异烟肼毒性的文献进行了综述。
