Glenn L D, Kumar P P
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68105.
J Natl Med Assoc. 1990 Feb;82(2):101-7.
Forty-four patients with histologically proven Hodgkin's disease underwent initial treatment with extended-field radiation therapy. Nineteen of these patients also received combination chemotherapy. For analysis, patients were assigned to three treatment groups: group 1 received radiation therapy only (25 patients); group 2 received combination chemotherapy followed by consolidative (low-dose extended-field) radiation therapy; and group 3 was treated with alternate chemotherapy and radiation therapy using the sandwich technique. The actuarial 5-year disease-free survival rates were 83% (group 1), 83% (group 2), and 100% (group 3). The overall actuarial survival rates were 96% (group 1), 92% (group 2), and 100% (group 3). No factor was identified as being of prognostic value in predicting relapse. We conclude that extended-field radiation therapy delivered in this manner is a safe and effective approach to the initial management of Hodgkin's disease.
44例经组织学证实的霍奇金病患者接受了扩大野放射治疗作为初始治疗。其中19例患者还接受了联合化疗。为进行分析，将患者分为三个治疗组：第1组仅接受放射治疗（25例患者）；第2组接受联合化疗，随后进行巩固性（低剂量扩大野）放射治疗；第3组采用三明治技术交替进行化疗和放射治疗。精算5年无病生存率分别为83%（第1组）、83%（第2组）和100%（第3组）。总精算生存率分别为96%（第1组）、92%（第2组）和100%（第3组）。未发现有任何因素在预测复发方面具有预后价值。我们得出结论，以这种方式进行的扩大野放射治疗是霍奇金病初始治疗的一种安全有效的方法。
