Fuller L M, Gamble J F, Velazquez W S, Rodgers R W, Butler J J, North L B, Martin R G, Gehan E A, Shullenberger C C
Cancer. 1980 Mar 15;45(6):1352-64. doi: 10.1002/1097-0142(19800315)45:6<1352::aid-cncr2820450614>3.0.co;2-v.
One hundred consecutive Stage IIIA and IIIB Hodgkin's disease patients were treated between July 1969 and September 1976, on a combined chemotherapy-radiotherapy program consisting of two courses of MOPP followed by radiotherapy to the mantle, abdomen, and pelvis. Eighty-eight patients completed radiotherapy to all disease sites. At the time of this analysis, the mean follow-up period for the 100 patients was 45 months; 70 patients had been followed three to seven years. Projected five-year survival and disease-free survival figures for the 100 patients were 80% and 68% respectively; corresponding results for the 88 patients were 90% and 78%. To determine whether any of the following prognostic factors influenced results for either the 100 or the 88 patients, survival curves were calculated for age, sex, constitutional symptoms, histopathology, method of staging, and status of the mediastinum. Other than age, none of these factors influenced survival significantly. However, disease-free survival figures were influenced adversely by mediastinal disease as well as age.
1969年7月至1976年9月期间，对100例连续的IIIA期和IIIB期霍奇金病患者采用了化疗-放疗联合方案进行治疗，该方案包括两个疗程的MOPP，随后对斗篷野、腹部和盆腔进行放疗。88例患者完成了所有病灶部位的放疗。在进行本次分析时，100例患者的平均随访时间为45个月；70例患者的随访时间为3至7年。100例患者的预计5年生存率和无病生存率分别为80%和68%；88例患者的相应结果为90%和78%。为了确定以下任何一个预后因素是否会影响100例或88例患者的治疗结果，计算了年龄、性别、全身症状、组织病理学、分期方法和纵隔状态的生存曲线。除年龄外，这些因素均未对生存产生显著影响。然而，无病生存率受到纵隔疾病和年龄的不利影响。
