Department of Neurology, Wake Forest University School of Medicine, Reynolds Tower, Winston-Salem, North Carolina 27157, USA.
Muscle Nerve. 2013 Feb;47(2):255-9. doi: 10.1002/mus.23525. Epub 2012 Oct 5.
Intensive care unit acquired weakness (ICU-AW) results from a complex mixture of nerve and muscle pathology, and early identification is challenging. This pilot study was designed to examine the ultrasonographic changes that occur in muscles during ICU hospitalization.
Patients admitted to the ICU for acute respiratory failure were enrolled prospectively and underwent serial muscle ultrasound for thickness and gray-scale assessment of the tibialis anterior, rectus femoris, abductor digiti minimi, biceps, and diaphragm muscles over 14 days.
Sixteen participants were enrolled. The tibialis anterior (P = 0.001) and rectus femoris (P = 0.041) had significant decreases in gray-scale standard deviation when analyzed over 14 days. No muscles showed significant changes in thickness.
Ultrasound is an informative technique for assessing muscles of patients in the ICU, and lower extremity muscles demonstrated increased homogeneity during ICU stays. This technique should be examined further for diagnosing and tracking those with ICU-AW.
重症监护病房获得性肌无力（ICU-AW）是由神经和肌肉病理的复杂混合引起的，早期识别具有挑战性。这项初步研究旨在检查 ICU 住院期间肌肉发生的超声变化。
前瞻性纳入因急性呼吸衰竭而入住 ICU 的患者，并在 14 天内对胫骨前肌、股直肌、趾短伸肌、肱二头肌和膈肌进行厚度和灰阶评估的连续肌肉超声检查。
纳入了 16 名参与者。胫骨前肌（P = 0.001）和股直肌（P = 0.041）的灰阶标准差在 14 天内分析时有显著下降。没有肌肉的厚度有显著变化。
超声是评估 ICU 患者肌肉的一种信息丰富的技术，下肢体肌在 ICU 期间表现出更高的均匀性。这种技术应该进一步检查，以诊断和跟踪那些有 ICU-AW 的患者。
