Akatsuka M, Sasaki H, Kataoka H, Hyodo M, Ohno F, Umegaki H
Department of Anesthesiology, Osaka Medical College, Takatsuki.
Masui. 1990 Jan;39(1):70-4.
The optimal dose and adverse effects of midazolam for premedication were evaluated in 45 patients undergoing local anesthesia. The patients were divided into 3 groups and administered midazolam intramuscularly: group-A 0.075 mg.kg-1, group-B 0.1mg.kg-1, group-C 0.125 mg.kg-1. In this study, concerning sedative and hypnotic effects, the administration of midazolam (0.075-0.1mg.kg-1) showed satisfactory results except in conduction anesthesia of upper extremities (brachial plexus block). However, severe decrease in PaO2 was observed in relatively younger patients. Therefore, it is necessary to observe patients carefully during perioperative period.
在45例接受局部麻醉的患者中评估了咪达唑仑用于术前用药的最佳剂量和不良反应。将患者分为3组并肌肉注射咪达唑仑：A组0.075mg·kg-1，B组0.1mg·kg-1，C组0.125mg·kg-1。在本研究中，关于镇静和催眠效果，除上肢传导麻醉（臂丛神经阻滞）外，咪达唑仑（0.075 - 0.1mg·kg-1）的给药显示出满意的结果。然而，在相对年轻的患者中观察到PaO2严重下降。因此，在围手术期有必要仔细观察患者。
