University of California, Los Angeles, CA, USA.
Lupus. 2013 Jan;22(1):99-105. doi: 10.1177/0961203312463110. Epub 2012 Oct 5.
The objective of this paper is to determine the incidence and prevalence of adult systemic lupus erythematosus (SLE) in a large US managed-care population.
Subject inclusion in the incidence cohort required a medical claim with an SLE diagnosis and a service date from 2003 to 2008 that satisfied the following criteria: 1) ≥18 years on service date; 2) continuously enrolled for 24 months before and 12 months after service date; 3) in the 12 months after service date, ≥ one inpatient claim or ≥ two office or ER visits with an SLE diagnosis; 4) no SLE diagnosis 24 months prior to service date; and 5) no SLE medications 12 months prior to service date. Prevalence cohort subjects were identified using a similar algorithm and were not required to satisfy criteria 4) and 5).
A total of 1,557 subjects were included in the incidence cohort, and 15,396 were included in the prevalence cohort. The overall age- and gender-adjusted SLE incidence rate (2003-2008) was 7.22 cases per 100,000 person-years. The annual prevalence of SLE (per 100,000 individuals) varied from 81.07 in 2003 to 102.94 in 2008.
The SLE incidence in this large managed-care plan with geographic diversity was slightly higher than previous estimates, and the prevalence was within the range of previous estimates.
本文旨在确定美国大型管理式医疗人群中成人系统性红斑狼疮（SLE）的发病率和患病率。
为了纳入发病率队列，患者需要满足以下标准的医疗索赔和 SLE 诊断，且服务日期在 2003 年至 2008 年之间：1）服务日期时年满 18 岁；2）在服务日期前 24 个月和后 12 个月内连续入保；3）在服务日期后 12 个月内，有≥1 次住院或≥2 次门诊或急诊就诊，且诊断为 SLE；4）服务日期前 24 个月内无 SLE 诊断；5）服务日期前 12 个月内无 SLE 药物治疗。采用类似的算法确定患病率队列的受试者，且不要求满足标准 4）和 5）。
共有 1557 例患者被纳入发病率队列，15396 例患者被纳入患病率队列。年龄和性别调整后的 SLE 总发病率（2003-2008 年）为 7.22 例/10 万人年。SLE 的年患病率（每 10 万人）从 2003 年的 81.07 例波动到 2008 年的 102.94 例。
该具有地域多样性的大型管理式医疗计划中的 SLE 发病率略高于之前的估计，而患病率则在之前的估计范围内。
