Center for the Neural Basis of Cognition, Carnegie Mellon University, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Science. 2012 Oct 5;338(6103):132-5. doi: 10.1126/science.1226405.
In monkeys deciding between alternative saccadic eye movements, lateral intraparietal (LIP) neurons representing each saccade fire at a rate proportional to the value of the reward expected upon its completion. This observation has been interpreted as indicating that LIP neurons encode saccadic value and that they mediate value-based decisions between saccades. Here, we show that LIP neurons representing a given saccade fire strongly not only if it will yield a large reward but also if it will incur a large penalty. This finding indicates that LIP neurons are sensitive to the motivational salience of cues. It is compatible neither with the idea that LIP neurons represent action value nor with the idea that value-based decisions take place in LIP neurons.
在猴子决定替代扫视眼动时，代表每个扫视的外侧顶内（LIP）神经元以与完成扫视后预期奖励值成正比的速率发射。这一观察结果被解释为表明 LIP 神经元编码扫视值，并且它们介导扫视之间基于价值的决策。在这里，我们表明，代表给定扫视的 LIP 神经元不仅在其将产生大奖励时强烈发射，而且在其将招致大惩罚时也强烈发射。这一发现表明 LIP 神经元对提示的动机显著性敏感。这既不符合 LIP 神经元代表动作值的观点，也不符合基于价值的决策发生在 LIP 神经元中的观点。
